Cutaneous drug reactions to antiepileptic drugs and relation with HLA alleles in the Turkish population

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dc.contributor.authorBuyukozturk, S.
dc.contributor.authorKekik, C.
dc.contributor.authorGokyigit, A. Z.
dc.contributor.authorFilik, F. I. Tezer
dc.contributor.authorKarakaya, G.
dc.contributor.authorSaygi, S.
dc.contributor.authorDursun, A. B.
dc.contributor.authorKirbas, S.
dc.contributor.authorTufekci, A.
dc.contributor.authorSin, A. Z.
dc.contributor.authorAydogdu, I.
dc.contributor.authorSorgun, M. H.
dc.contributor.authorAydin, N.
dc.contributor.authorGelincik, A.
dc.contributor.authorColakoglu, B.
dc.contributor.authorCelik, G.
dc.contributor.authorOguz, F.
dc.date.accessioned2019-10-27T10:46:16Z
dc.date.available2019-10-27T10:46:16Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground and objective. Many studies have shown associations between HLAB*15: 02, HLA-A*31: 01 and carbamazepine (CBZ)-induced delayed cutaneous hypersensitivity reactions. The aim of this study is to evaluate a possible association between delayed cutaneous reactions to antiepileptic drugs (AEDs) and certain HLA-A and HLA-B alleles in the Turkish population. Methods. The study consisted of 3 groups: Group I (reactive group) included the patients who had documented delayed cutaneous reactions to any antiepileptic drug. Group II (non-reactive group) included the patients who have been on antiepileptic treatment at least for three months without any adverse reactions. Group III consisted of healthy subjects. The HLA-A and B alleles were analyzed in all groups. Results. Forty patients (29 female) had experienced different hypersensitivity reactions due to AEDs: maculopapular exanthema (26 patients), Stevens-Johnson syndrome (6 patients), drug rash with eosinophilia and systemic symptoms (7 patients), toxic epidermal necrolysis (1 patient). Lamotrigine (11) and CBZ (10) were the most common culprit drugs involved in the reactions. The HLA-B*15: 02 was not present in any of the study groups. However, HLA-B* 35: 02 was found in 4 patients from the reactive group, while it was not observed in non-reactive patients and was detected in only one healthy subject (p = 0.021). Conclusion. Although our preliminary results did not indicate a strong allele association with AED hypersensitivity, HLA-B* 35: 02 appears to be a candidate allele for MPE /DRESS /DIHSS induced by AED's in Turkish population. Further studies with a larger sample size may result in more comprehensive data about the genetic tendency for AED hypersensitivity in the Turkish population.en_US
dc.description.sponsorshipIstanbul UniversityIstanbul University [36857]en_US
dc.description.sponsorshipThis study was supported by the Research Found of the Istanbul University. Project no: 36857.en_US
dc.identifier.doi10.23822/EurAnnACI.1764-1489.23en_US
dc.identifier.endpage41en_US
dc.identifier.issn1764-1489
dc.identifier.issue1en_US
dc.identifier.pmid29350020en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage36en_US
dc.identifier.urihttps://doi.org/10.23822/EurAnnACI.1764-1489.23
dc.identifier.urihttps://hdl.handle.net/11454/31274
dc.identifier.volume50en_US
dc.identifier.wosWOS:000429109500005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMattioli 1885en_US
dc.relation.ispartofEuropean Annals of Allergy and Clinical Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectantiepilepticsen_US
dc.subjectcarbamazepineen_US
dc.subjectHLA-A alleleen_US
dc.subjectHLA-B alleleen_US
dc.subjectdrug hypersensitivityen_US
dc.subjectdelayed reactionsen_US
dc.subjectSJSen_US
dc.subjectTENen_US
dc.subjectMPEen_US
dc.titleCutaneous drug reactions to antiepileptic drugs and relation with HLA alleles in the Turkish populationen_US
dc.typeArticleen_US

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