Bio-based topical system for enhanced salicylic acid delivery: preparation and performance of gels

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dc.contributor.authorLangasco, Rita
dc.contributor.authorSpada, Gianpiera
dc.contributor.authorTanriverdi, Sakine Tuncay
dc.contributor.authorRassu, Giovanna
dc.contributor.authorGiunchedi, Paolo
dc.contributor.authorOzer, Ozgen
dc.contributor.authorGavini, Elisabetta
dc.date.accessioned2019-10-27T23:09:05Z
dc.date.available2019-10-27T23:09:05Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectivesNew salicylic acid (SA)-loaded gels were developed using excipients made from renewable materials, and our goal was to improve drug permeation in the topical treatment of acne vulgaris. MethodsWe studied the preparation parameters to obtain suitable gel formulations. Only naturally occurring polymers were used as gelling agents. Two hydrogels and three lipogels were selected and characterized in terms of drug loading, pH, viability cells, rheology, mechanical properties and in vitro permeation; these hydrogels and lipogels were compared with the traditional ointment. We also evaluated skin parameters before and after gel application. Key findingsThe formulations that we studied are non-Newtonian fluids; they have high drug loading and suitable mechanical properties. Lipogels exhibit a slower and more linear in vitro permeation profile compared with hydrogels. The different vehicles that we used affected drug permeation and improve patient compliance. Cytotoxicity studies suggest that all of the formulations are non-toxic. ConclusionsLipogels demonstrate appropriate technological features and improved performance compared with the traditional ointment with regard to their composition. Lipogels may represent a new bio-based topical system for SA delivery. The use of green' excipients leads to skin-friendly' formulations that are able to satisfy environmental safety.en_US
dc.description.sponsorshipRegione Autonoma Sardegna (RAS)Russian Academy of SciencesRegione Sardegna; Obiettivo competitivita regionale e occupazione; Asse IV Capitale umano; Linea di Attivita l.3.1en_US
dc.description.sponsorshipDr Langasco thanks Regione Autonoma Sardegna (RAS), Obiettivo competitivita regionale e occupazione, Asse IV Capitale umano, Linea di Attivita l.3.1, for supporting PhD programme.en_US
dc.identifier.doi10.1111/jphp.12582en_US
dc.identifier.endpage1009en_US
dc.identifier.issn0022-3573
dc.identifier.issn2042-7158
dc.identifier.issue8en_US
dc.identifier.pmid27293193en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage999en_US
dc.identifier.urihttps://doi.org/10.1111/jphp.12582
dc.identifier.urihttps://hdl.handle.net/11454/52509
dc.identifier.volume68en_US
dc.identifier.wosWOS:000379975200005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Pharmacy and Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectgelen_US
dc.subjectgreen formulationen_US
dc.subjectrenewable resourcesen_US
dc.subjectskin permeationen_US
dc.subjecttopical deliveryen_US
dc.titleBio-based topical system for enhanced salicylic acid delivery: preparation and performance of gelsen_US
dc.typeArticleen_US

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