The effects of extended polymerization time for different resin composites on reactive oxygen species production and cell viability

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dc.contributor.authorOzkaya, Cigdem Atalayin
dc.contributor.authorTezel, Huseyin
dc.contributor.authorArmagan, Guliz
dc.contributor.authorTuzcu, Fulya
dc.contributor.authorSahbaz, Ufuk
dc.contributor.authorDagci, Taner
dc.date.accessioned2021-05-03T20:33:30Z
dc.date.available2021-05-03T20:33:30Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose: The present study was conducted to determine oxidative stress and cell viability after contact with resin composites polymerized for different times. Methods: Disk-shaped specimens of Admira Fusion. Ceram X One Universal. Solare x and Filtek Z550 (n = 12) were prepared, and two subgroups with polymerization times of 20 and 40 s were employed. The specimens were incubated with mouse fibroblast cells for 48 and 72 h, and changes in reactive oxygen species (ROS) production and cellular viability were determined by an assay with a cell-permeable fluorescent dye, 2',7'-dichlorodihydrofluorescein diacetate (H2DCF-DA), and the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, respectively. Results: At 72 h, ROS production in the presence of Admira Fusion polymerized for 40 s was reduced relative to that in the presence of Admira Fusion polymerized for 20 s (P < 0.05). Cell viability was maximal in the Admira Fusion and Solare x groups and there was no difference relative to the control group at 48 h. Cell viability was higher in the Admira Fusion and Solare x groups polymerized for 40 s than for the same materials polymerized for 20 sat 72 h (P < 0.05). Conclusion: Extension of the polymerizaton lime has a material-specific effect and may be used as a strategy to increase the biocompability of resin composites.en_US
dc.identifier.doi10.2334/josnusd.20-0034en_US
dc.identifier.endpage49en_US
dc.identifier.issn1343-4934
dc.identifier.issn1880-4926
dc.identifier.issue1en_US
dc.identifier.pmid33148930en_US
dc.identifier.scopus2-s2.0-85098542501en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage46en_US
dc.identifier.urihttps://doi.org/10.2334/josnusd.20-0034
dc.identifier.urihttps://hdl.handle.net/11454/70053
dc.identifier.volume63en_US
dc.identifier.wosWOS:000601404800011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNihon Univ, School Dentistryen_US
dc.relation.ispartofJournal of Oral Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcell viabilityen_US
dc.subjectpolymerization timeen_US
dc.subjectreactive oxygen speciesen_US
dc.subjectresin compositeen_US
dc.titleThe effects of extended polymerization time for different resin composites on reactive oxygen species production and cell viabilityen_US
dc.typeArticleen_US

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