Prevalence of toxoplasmosis and genetic characterization of Toxoplasma gondii strains isolated in wild birds of prey and their relation with previously isolated strains from Turkey

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dc.contributor.authorKarakavuk, Muhammet
dc.contributor.authorAldemir, Duygu
dc.contributor.authorMercier, Aurelien
dc.contributor.authorSahar, Esra Atalay
dc.contributor.authorCan, Huseyin
dc.contributor.authorMurat, Jean-Benjamin
dc.contributor.authorDonduren, Omer
dc.contributor.authorCan, Sengul
dc.contributor.authorOzdemir, Huseyin Gokhan
dc.contributor.authorDoskaya, Aysu Degirmenci
dc.contributor.authorPektas, Bayram
dc.contributor.authorDarde, Marie-Laure
dc.contributor.authorGuruz, Adnan Yuksel
dc.contributor.authorDoskaya, Mert
dc.date.accessioned2019-10-27T10:06:27Z
dc.date.available2019-10-27T10:06:27Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractToxoplasma gondii is a protozoon parasite that causes congenital toxoplasmosis, as well as other serious clinical presentations, in immune compromised humans. Analyses of the prevalence and genotyping of strains from the definitive host and intermediate hosts will help to understanding the circulation of the different strains and elucidating the role of the genotype (s) in human toxoplasmosis. Turkey has a specific geographic location bridging Africa, Europe, and Asia. We hypothesized that T. gondii strains may have been transferred to Turkey from these continents via migratory birds or vice versa. The present study aimed to assess the prevalence of toxoplasmosis in wild birds of prey of Izmir and Manisa provinces as well as genetically characterize T. gondii strains from these wild birds to show the relation between bird strains and neighboring stray cats as well as human strains previously isolated in Turkey. Tissues obtained from 48 wild birds were investigated for the presence of T. gondii DNA and then bioassayed in mouse. Isolated strains were genotyped using 15 microsatellite markers. The prevalence of T. gondii DNA was found to be 89.6% (n: 43/48) in wild birds. Out of 43 positive samples, a total of 14 strains were genotyped by 15 microsatellite markers. Among them, eight were type II, three were type III and three were mixture of genotypes (two type II/II and one was II/III). These are the first data that showed the presence of T. gondii and types II and III genotypes in wild birds of Turkey. Moreover, Africa 1 was not detected. In addition, cluster analysis showed that T. gondiistrains within type II and III lineage have close relation with strains previously isolated from stray cats in Izmir. Further studies are required to isolate more strains from human cases, other intermediate hosts, and water sources to reveal this relation.en_US
dc.description.sponsorshipScientific Research Projects Branch Directorate of Ege University, TurkeyEge University [2014-TIP-073]en_US
dc.description.sponsorshipThis study was supported by the grant given by the Scientific Research Projects Branch Directorate of Ege University, Turkey (Grant No: 2014-TIP-073) to A.Y.G. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.identifier.doi10.1371/journal.pone.0196159en_US
dc.identifier.issn1932-6203
dc.identifier.issue4en_US
dc.identifier.pmid29668747en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0196159
dc.identifier.urihttps://hdl.handle.net/11454/30457
dc.identifier.volume13en_US
dc.identifier.wosWOS:000430290200079en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPublic Library Scienceen_US
dc.relation.ispartofPlos Oneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titlePrevalence of toxoplasmosis and genetic characterization of Toxoplasma gondii strains isolated in wild birds of prey and their relation with previously isolated strains from Turkeyen_US
dc.typeArticleen_US

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