Brain regions associated with risk and resistance for bipolar I disorder: a voxel-based MRI study of patients with bipolar disorder and their healthy siblings

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dc.contributor.authorEker, Cagdas
dc.contributor.authorSimsek, Fatma
dc.contributor.authorYilmazer, Evrim Ebru
dc.contributor.authorKitis, Omer
dc.contributor.authorCinar, Cem
dc.contributor.authorEker, Ozlem Donat
dc.contributor.authorCoburn, Kerry
dc.contributor.authorGonul, Ali Saffet
dc.date.accessioned2019-10-27T22:15:12Z
dc.date.available2019-10-27T22:15:12Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectiveBipolar I disorder is a highly heritable disorder but not all siblings manifest with the illness, even though they may share similar genetic and environmental risk factors. Thus, sibling studies may help to identify brain structural endophenotypes associated with risk and resistance for the disorder. MethodsStructural magnetic resonance imaging (MRI) scans were acquired for 28 euthymic patients with bipolar disorder, their healthy siblings, and 30 unrelated healthy controls. Statistical Parametric Mapping 8 (SPM8) was used to identify group differences in regional gray matter volume by voxel-based morphometry (VBM). ResultsUsing analysis of covariance, gray matter analysis of the groups revealed a group effect indicating that the left orbitofrontal cortex [Brodmann area (BA) 11] was smaller in patients with bipolar disorder than in unrelated healthy controls [F=14.83, p<0.05 (family-wise error); 7mm(3)]. Paired t-tests indicated that the orbitofrontal cortex of patients with bipolar disorder [t=5.19, p<0.05 (family-wise error); 37mm(3)] and their healthy siblings [t=3.89, p<0.001 (uncorrected); 63mm(3)] was smaller than in unrelated healthy controls, and that the left dorsolateral prefrontal cortex was larger in healthy siblings than in patients with bipolar disorder [t=4.28, p<0.001 (uncorrected); 323mm(3)] and unrelated healthy controls [t=4.36, p<0.001 (uncorrected); 245mm(3)]. Additional region-of-interest analyses also found volume deficits in the right cerebellum of patients with bipolar disorder [t=3.92, p<0.001 (uncorrected); 178mm(3)] and their healthy siblings [t=4.23, p<0.001 (uncorrected); 489mm(3)], and in the left precentral gyrus of patients with bipolar disorder [t=3.61, p<0.001 (uncorrected); 115mm(3)] compared to unrelated healthy controls. ConclusionsThe results of this study suggest that a reduction in the volume of the orbitofrontal cortex, which plays a role in the automatic regulation of emotions and is a part of the medial prefrontal network, is associated with the heritability of bipolar disorder. Conversely, increased dorsolateral prefrontal cortex volume may be a neural marker of a resistance factor as it is part of a network of voluntary emotion regulation and balances the effects of the disrupted automatic emotion regulation system.en_US
dc.description.sponsorshipInternational Society for Bipolar Disorders-affiliated Turkish Bipolar Disorders Society; Ege University School of MedicineEge University [2009-D-00017]en_US
dc.description.sponsorshipThis work is partly supported by the research grant award of the International Society for Bipolar Disorders-affiliated Turkish Bipolar Disorders Society and a research grant from Ege University School of Medicine (Grant #2009-D-00017). No sponsor or funder played any role in the design and conduct of the study; the collection, management, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript. The authors would like to thank Selami Aksoy, M. D. for his help in recruiting the sample, and the referees for their invaluable comments.en_US
dc.identifier.doi10.1111/bdi.12181en_US
dc.identifier.endpage261en_US
dc.identifier.issn1398-5647
dc.identifier.issn1399-5618
dc.identifier.issue3en_US
dc.identifier.pmid24589068en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage249en_US
dc.identifier.urihttps://doi.org/10.1111/bdi.12181
dc.identifier.urihttps://hdl.handle.net/11454/50135
dc.identifier.volume16en_US
dc.identifier.wosWOS:000335771100004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofBipolar Disordersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbipolar disorderen_US
dc.subjectdorsolateral prefrontal cortexen_US
dc.subjecthigh risken_US
dc.subjectmagnetic resonance imagingen_US
dc.subjectorbitofrontal cortexen_US
dc.subjectrelativesen_US
dc.subjectresistanceen_US
dc.subjectvoxel based morphometryen_US
dc.titleBrain regions associated with risk and resistance for bipolar I disorder: a voxel-based MRI study of patients with bipolar disorder and their healthy siblingsen_US
dc.typeArticleen_US

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