Executive and verbal working memory dysfunction in first-degree relatives of patients with bipolar disorder

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dc.contributor.authorBora, Emre
dc.contributor.authorVahip, Simavi
dc.contributor.authorAkdeniz, Fisun
dc.contributor.authorIlerisoy, Hatice
dc.contributor.authorAldemir, Ebru
dc.contributor.authorAlkan, Muege
dc.date.accessioned2019-10-27T20:22:22Z
dc.date.available2019-10-27T20:22:22Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractThe authors aimed to investigate cognitive performance of first-degree relatives of probands with bipolar disorder (BD). They hypothesized that the relatives of BD patients would have impaired performance on cognitive tests of frontal-executive functions. A neuropsychological battery was administered to 34 first-degree relatives of BD probands and 25 control subjects. Relatives showed significant impairment in verbal working memory and executive function. Verbal memory and psychomotor performances of relatives were not different from control subjects. One particular component of executive function, cognitive flexibility, was associated with family history of mood episodes with psychotic features. Verbal working memory and executive function deficits may be useful endophenotypic markers of genetic vulnerability to BD. (C) 2007 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.psychres.2007.09.002en_US
dc.identifier.endpage324en_US
dc.identifier.issn0165-1781
dc.identifier.issue3en_US
dc.identifier.pmid18977035en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage318en_US
dc.identifier.urihttps://doi.org/10.1016/j.psychres.2007.09.002
dc.identifier.urihttps://hdl.handle.net/11454/41890
dc.identifier.volume161en_US
dc.identifier.wosWOS:000261718700007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofPsychiatry Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBipolar disorderen_US
dc.subjectRelativesen_US
dc.subjectNeuropsychologyen_US
dc.subjectWorking memoryen_US
dc.subjectSustained attentionen_US
dc.subjectExecutive functionen_US
dc.titleExecutive and verbal working memory dysfunction in first-degree relatives of patients with bipolar disorderen_US
dc.typeArticleen_US

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