Association of Vitamin D Deficiency with Increased Pulse Wave Velocity and Augmentation Index in Children With Chronic Kidney Disease

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dc.contributor.authorConka, Secil
dc.contributor.authorMir, Sevgi
dc.contributor.authorDogan, Eser
dc.contributor.authorTutar, Zulal Ulger
dc.date.accessioned2019-10-27T10:02:40Z
dc.date.available2019-10-27T10:02:40Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction. It is known that in children with chronic kidney disease (CKD), cardiovascular damage starts in the form of arterial stiffness. There are risk factors other than the traditional ones such as arterial stiffness hypertension, obesity, hypercholesterolemia, and insulin resistance. Vitamin D deficiency is rather common in CKD, and it was introduced as a risk factor for atherosclerosis; however, its relationship with arterial stiffness is not known completely. The purpose of this study was to research the relationship between 25-hydroxyvitamin D levels and arterial stiffness. Materials and Methods. Arterial stiffness was evaluated by measuring augmentation index (AI) and pulse wave velocity (PWV) from the radial and carotid arteries with a Vicorder. The 25-hydroxyvitamin D levels were measured by an immunoassay method. Results. In the 81 CKD patients (mean age, 13.21 +/- 6.02 years; mean body mass index, 19.42 +/- 5.12 kg/m(2); and 56.8% male), the mean vitamin D level was 60.71 +/- 39.52 ng/mL, the mean AI was 7.93 +/- 7.77%, and the mean PWV was 9.79 +/- 4.36 m/s. Serum levels of 25-hydroxyvitamin D was correlated with AI (r = -0.482, P = 0.001) and PWV (r = -0.57, P = .001). Conclusions. In this study, it was proven that vitamin D deficiency in children was related to nondiabetic and nondialysis CKD.en_US
dc.identifier.endpage280en_US
dc.identifier.issn1735-8582
dc.identifier.issn1735-8604
dc.identifier.issue5en_US
dc.identifier.pmid30367018en_US
dc.identifier.startpage275en_US
dc.identifier.urihttps://hdl.handle.net/11454/30022
dc.identifier.volume12en_US
dc.identifier.wosWOS:000448436000004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIranian Soc Nephrolgyen_US
dc.relation.ispartofIranian Journal of Kidney Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpulse wave velocityen_US
dc.subjectarterial stiffnessen_US
dc.subjectchilden_US
dc.subjectchronic kidney diseaseen_US
dc.subjectvitamin Den_US
dc.titleAssociation of Vitamin D Deficiency with Increased Pulse Wave Velocity and Augmentation Index in Children With Chronic Kidney Diseaseen_US
dc.typeArticleen_US

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