Immunosuppression after Liver Transplantation in Pediatric Population

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dc.authorscopusid47461699000
dc.authorscopusid6602866442
dc.authorscopusid7007130335
dc.contributor.authorUmman, V.
dc.contributor.authorZeytunlu, M.
dc.contributor.authorEmre, S.
dc.date.accessioned2024-08-25T18:52:08Z
dc.date.available2024-08-25T18:52:08Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractPediatric liver transplantation has become the standard of care for children with end-stage liver disease, owing to advancement of surgical techniques including split liver transplantation and living donor liver transplantation which increased available organs. Furthermore, technological advancements, better understanding of disease process, patient selection and improved pre- and postoperative ICU care, better managing of short- and long-term complications secondary to increasing experience, and team effort have played important role for patient outcomes and satisfaction. In addition to these factors, understanding the immunological issues and development of new immunosuppressive medications have made the field of liver transplantation as an acceptable treatment modality. These advancements improved outcomes dramatically to 94% 1-year survival [1, 2]. Immunosuppressive therapy has substantial contribution in these results by prevention of rejection and early complications. On the other hand, immunosuppressive management of pediatric recipients has continued to be challenging for various reasons. In this chapter we aim to overview the current immunosuppressive medications, their mechanism of actions, pharmacokinetics, pharmacodynamics, side effects, and immunosuppressive strategies/protocols. © Springer Nature Singapore Pte Ltd. 2023.en_US
dc.identifier.doi10.1007/978-981-19-6909-6_31
dc.identifier.endpage459en_US
dc.identifier.isbn9789811969096; 9789811969089
dc.identifier.scopus2-s2.0-85171514558en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage443en_US
dc.identifier.urihttps://doi.org/10.1007/978-981-19-6909-6_31
dc.identifier.urihttps://hdl.handle.net/11454/102855
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofPediatric Solid Organ Transplantation: A Practical Handbooken_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectAdherenceen_US
dc.subjectImmunosuppressionen_US
dc.subjectImmunosuppressive medicationen_US
dc.subjectLiver transplantationen_US
dc.subjectMechanism of actionen_US
dc.subjectPediatricsen_US
dc.subjectSide effectsen_US
dc.titleImmunosuppression after Liver Transplantation in Pediatric Populationen_US
dc.typeBook Chapteren_US

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