Immunosuppression after Liver Transplantation in Pediatric Population
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Nature
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Pediatric liver transplantation has become the standard of care for children with end-stage liver disease, owing to advancement of surgical techniques including split liver transplantation and living donor liver transplantation which increased available organs. Furthermore, technological advancements, better understanding of disease process, patient selection and improved pre- and postoperative ICU care, better managing of short- and long-term complications secondary to increasing experience, and team effort have played important role for patient outcomes and satisfaction. In addition to these factors, understanding the immunological issues and development of new immunosuppressive medications have made the field of liver transplantation as an acceptable treatment modality. These advancements improved outcomes dramatically to 94% 1-year survival [1, 2]. Immunosuppressive therapy has substantial contribution in these results by prevention of rejection and early complications. On the other hand, immunosuppressive management of pediatric recipients has continued to be challenging for various reasons. In this chapter we aim to overview the current immunosuppressive medications, their mechanism of actions, pharmacokinetics, pharmacodynamics, side effects, and immunosuppressive strategies/protocols. © Springer Nature Singapore Pte Ltd. 2023.
Açıklama
Anahtar Kelimeler
Adherence, Immunosuppression, Immunosuppressive medication, Liver transplantation, Mechanism of action, Pediatrics, Side effects
Kaynak
Pediatric Solid Organ Transplantation: A Practical Handbook
WoS Q Değeri
Scopus Q Değeri
N/A
