Low-Dose Fluvastatin Prevents the Functional Alterations of Endothelium Induced by Short-Term Cholesterol Feeding in Rabbit Carotid Artery

Basit Öğe Kaydı
dc.contributor.authorSevin, Gulnur
dc.contributor.authorAkcay, Yasemin Delen
dc.contributor.authorOzsarlak-Sozer, Gonen
dc.contributor.authorYasa, Mukadder
dc.date.accessioned2019-10-27T21:34:09Z
dc.date.available2019-10-27T21:34:09Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstract3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, commonly known as statins, are the medical treatment of choice for hypercholesterolemia. In addition to lowering serum-cholesterol levels, statins appear to promote pleiotropic effects that are independent of changes in serum cholesterol. In this study, we investigated the effects of low-dose fluvastatin on antioxidant enzyme activities (superoxide dismutase, SOD; catalase), total nitrite/nitrate levels, and vascular reactivity in 2% cholesterol-fed rabbits. This diet did not generate any fatty streak lesions on carotid artery wall. However, SOD activity significantly increased with cholesterol feeding whereas the catalase activities decreased. The levels of nitrite/nitrate, stable products of NO degradation, diminished. Moreover, dietary cholesterol reduced vascular responses to acetylcholine, but contractions to serotonin were augmented. Fluvastatin treatment abrogated the cholesterol-induced increase in SOD, increased the levels of nitric oxide metabolites in tissue, and restored both the impaired vascular responses to acetylcholine and the augmented contractile responses to serotonin without affecting plasma-cholesterol levels. Phenylephrine contractions and nitroglycerine vasodilatations did not change in all groups. This study indicated that fluvastatin treatment performed early enough to improve impaired vascular responses may delay cardiovascular complications associated with several cardiovascular diseases.en_US
dc.description.sponsorshipEge UniversityEge University [99ECZ016]en_US
dc.description.sponsorshipFluvastatin was a gift from Novartis (Istanbul, Turkey). The authors are grateful to Professor E.Y. Sozmen for helping with biochemical measurements and Professor E. Ozer for the morphological examinations. This study was supported by a Grant from the Ege University Scientific Research Fund (99ECZ016).en_US
dc.identifier.doi10.1100/2012/671728en_US
dc.identifier.endpage8en_US
dc.identifier.issn1537-744X
dc.identifier.pmid22547992en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1100/2012/671728
dc.identifier.urihttps://hdl.handle.net/11454/45577
dc.identifier.wosWOS:000303254500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.ispartofScientific World Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleLow-Dose Fluvastatin Prevents the Functional Alterations of Endothelium Induced by Short-Term Cholesterol Feeding in Rabbit Carotid Arteryen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu