Nine Generations of Selection for High and Low Nicotine Intake in Outbred Sprague-Dawley Rats

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dc.contributor.authorNesil, Tanseli
dc.contributor.authorKanit, Lutfiye
dc.contributor.authorLi, Ming D.
dc.contributor.authorPogun, Sakire
dc.date.accessioned2019-10-27T22:08:36Z
dc.date.available2019-10-27T22:08:36Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractPrevious animal studies have revealed significant involvement of genetics in nicotine intake; however, the extent of the genetic contribution to this behavior has not been well addressed. We report the first study of nine generations of selection for high and low voluntary nicotine intake in outbred Sprague-Dawley rats. Bidirectional mass selection resulted in progressively greater nicotine consumption in the high nicotine-preferring line but no decrease in nicotine intake in the low nicotine-preferring line across generations. Our estimated realized heritability for high voluntary nicotine intake is 0.26 vs close to zero for low voluntary nicotine intake. In contrast, we found no differences between the lines across generations for saccharine intake. These selected lines may provide useful animal models for identifying susceptibility and resistance genes and variants for controlling voluntary nicotine intake in rodents, although we recognize that more generations of selection of these two lines and independent replication of our selection for high and low nicotine-preferring lines are needed.en_US
dc.description.sponsorshipEge UniversityEge University [001 BAM 2006]; National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [DA-012844]en_US
dc.description.sponsorshipWe are grateful to Dr. Gonca Mola, Merve Evren, and Tuna Nesil and Muzeyyen Ugur for their assistance in data collection and to Professor Qin Zhang of China Agricultural University for calculating inbreeding coefficients for the study. The animal-related study was funded by the Ege University Research Fund (Grant 001 BAM 2006). The analysis of data and preparation of this report were supported in part by National Institutes of Health grant DA-012844 to MDL.en_US
dc.identifier.doi10.1007/s10519-013-9605-yen_US
dc.identifier.endpage444en_US
dc.identifier.issn0001-8244
dc.identifier.issn1573-3297
dc.identifier.issue5en_US
dc.identifier.pmid23912820en_US
dc.identifier.startpage436en_US
dc.identifier.urihttps://doi.org/10.1007/s10519-013-9605-y
dc.identifier.urihttps://hdl.handle.net/11454/49205
dc.identifier.volume43en_US
dc.identifier.wosWOS:000323737700007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofBehavior Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNicotineen_US
dc.subjectSelectionen_US
dc.subjectBreedingen_US
dc.subjectRealized heritabilityen_US
dc.subjectRaten_US
dc.titleNine Generations of Selection for High and Low Nicotine Intake in Outbred Sprague-Dawley Ratsen_US
dc.typeArticleen_US

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