Effects of volatile substance abuse on the respiratory system in adolescents

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dc.contributor.authorBuker, Halime S. C.
dc.contributor.authorDemir, Esen
dc.contributor.authorYuncu, Zeki
dc.contributor.authorGulen, Figen
dc.contributor.authorMidyat, Levent
dc.contributor.authorTanac, Remziye
dc.date.accessioned2019-10-27T21:24:06Z
dc.date.available2019-10-27T21:24:06Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: Inhalant abuse is a prevalent and often overlooked form of substance abuse in adolescents. Chronic inhalant abuse can damage respiratory, cardiac, renal, hepatic, and neurologic systems. This study aims to determine the physiologic effects of inhaling solvents on the respiratory functions. Methods: The general health status of the subjects was assessed by history taking, physical examination and a questionnaire which was designed to show the severity of respiratory symptoms. Spirometry, ventilation/perfusion scintigraphy, and high resolution computed tomography (HRCT) were performed to assess pulmonary functions and anatomy. Results: Thirty-one male volatile substance abusers and 19 control subjects were included in the study. The mean age of onset of inhalant use was 14.6 +/- 2.2 (9-18) years and duration of drug use was 3.7 +/- 1.7 years. The most common respiratory symptoms in volatile substance abusers were nasal congestion (45.2%), sputum (38.7%), exercise intolerance (32.3%) and cough (22.6%). Results of spirometric studies showed 12 (41.4%) subjects with low FVC values < 80% of predicted, indicative of restrictive ventilatory pattern in the study group. Although the difference was not statistically significant, restrictive ventilatory pattern was higher in the study group. There was no statistically significant correlation between restrictive ventilatory pattern and the age of onset/duration/frequency of inhalant abuse, respiratory symptoms and scintigraphic abnormalities. Subjects who had restrictive pattern in their pulmonary function tests were more likely to have abnormal findings at HRCT (p < 0.01). Conclusion: This study has shown a positive correlation between volatile substance abuse and the development of restrictive ventilatory pattern, but more comprehensive studies are needed for more precise conclusions.en_US
dc.identifier.endpage168en_US
dc.identifier.issn1828-695X
dc.identifier.issue3en_US
dc.identifier.pmid22958270en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage161en_US
dc.identifier.urihttps://hdl.handle.net/11454/44364
dc.identifier.volume6en_US
dc.identifier.wosWOS:000292793900004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNovamediaen_US
dc.relation.ispartofMultidisciplinary Respiratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAbuseen_US
dc.subjectadolescenten_US
dc.subjectinhalanten_US
dc.subjectrespiratory systemen_US
dc.titleEffects of volatile substance abuse on the respiratory system in adolescentsen_US
dc.typeArticleen_US

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