Short-term effects of irbesartan treatment on microalbuminuria in patients with normotensive type 2 diabetes.

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dc.contributor.authorCetinkalp S.S.
dc.contributor.authorKaradeniz M.M.
dc.contributor.authorErdogan M.A.
dc.contributor.authorOzgen G.A.
dc.contributor.authorYilmaz C.O.
dc.date.accessioned2019-10-26T23:58:16Z
dc.date.available2019-10-26T23:58:16Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractOBJECTIVE: To observe the short-term effects of irbesartan treatment on microalbuminuria in patients with normotensive type 2 diabetes. METHODS: A total of 40 normotensive type 2 diabetes patients (mean age 55.1+/-11.4 years) who had microalbuminuria were included in this non-comparative and prospective research study. The study took place in Ege University Hospital, Bornova-Izmir, Turkey, between January 2005 and April 2005. Patients were treated with irbesartan 300mg/day for 3 months. Physical examination, medical history, systolic and diastolic blood pressure levels, microalbuminuria, diabetes markers fasting and non-fasting blood glucose, glycosylated hemoglobin [HbA1c], lipid profile, creatinine and urea were obtained at baseline and after 3 months of irbesartan treatment. The primary assessment criterion was the change in microalbuminuria. RESULTS: The mean microalbuminuria level at baseline was 110.8+/-93.1mg/24 hours. It significantly decreased to 45.6+/-62.5mg/24 hours at the end of 3 months of irbesartan treatment (p<0.001). When patients were stratified according to the change in the microalbuminuria status after treatment, 90% of them either returned to normo albuminuria or their microalbuminuria decreased. Both diastolic and systolic blood pressures, fasting and non-fasting blood glucose, and HbA1c were found to be significantly decreased after 3 months of irbesartan treatment compared to pre-treatment values. The positive effect of irbesartan on microalbuminuria occurs independently from HbA1c, fasting blood glucose, and blood pressures. CONCLUSION: The short-term treatment of irbesartan is effective to decrease microalbuminuria in normotensive type 2 diabetes patients, independent of its antihypertensive effect. There is a need for multicenter prospective studies to investigate this further.en_US
dc.identifier.endpage1418en_US
dc.identifier.issn0379-5284
dc.identifier.issue10en_US
dc.identifier.pmid18946564en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1414en_US
dc.identifier.urihttps://hdl.handle.net/11454/21184
dc.identifier.volume29en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofSaudi medical journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleShort-term effects of irbesartan treatment on microalbuminuria in patients with normotensive type 2 diabetes.en_US
dc.typeArticleen_US

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