Exploring the efficacy and tolerability of two-injection start regimen of long-acting aripiprazole: A descriptive case series analysis

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dc.authorid0000-0003-2116-3952
dc.authorid0000-0002-0505-1662
dc.authorid0000-0001-5496-9587
dc.contributor.authorSungur, Ibrahim
dc.contributor.authorKeskin, Kaan
dc.contributor.authorAktas, Elif Ozge
dc.contributor.authorEker, Mehmet Cagdas
dc.date.accessioned2025-04-18T13:05:26Z
dc.date.available2025-04-18T13:05:26Z
dc.date.issued2024
dc.departmentEge Üniversitesi, Tıp Fakültesi, Dahili Bilimler Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBipolar disorder is the fourth most debilitating psychiatric illness in the world regarding Disability Adjusted Life Years and manic episodes frequently lead to lengthy hospitalizations which restricts the freedom of patients. Therefore, decreasing the length of hospitalization with safer agents is of utmost importance in the treatment of manic episodes. Aripiprazole is a medication known for its efficacy in managing mania associated with bipolar disorder. Aripiprazole long-acting injection is approved for the treatment of mania associated with bipolar disorder in adults and found efficacious as a maintenance treatment. In the treatment of schizophrenia, European Medicines Agency has approved a simplified starting strategy of aripiprazole once a month, with two 400 mg injections and a single oral 20 mg dose of aripiprazole. To the best of our knowledge, no previous study has reported the safety, tolerability, and efficacy of this regimen in adult bipolar disorder patients. We present a case series of eight patients who were admitted to the hospital in a manic episode with psychotic features. We observed that the double injection start regimen was effective in treating manic symptoms with no specific severe adverse events. We conclude from a small sample of manic patients that a double injection start regimen has good efficacy and tolerability. Evaluate the safety, tolerability, and efficacy of the TIS regimen of Aripiprazole in treating manic episodes in bipolar disorder. Retrospective observational study involving eight hospitalized patients with bipolar disorder in a manic episode.image
dc.identifier.citationSungur, I., Keskin, K., Aktaş, E. Ö., & Eker, M. Ç. (2024). Exploring the efficacy and tolerability of two‐injection start regimen of long‐acting aripiprazole: A descriptive case series analysis. Neuropsychopharmacology Reports, 44(4), 857-862.
dc.identifier.doi10.1002/npr2.12489
dc.identifier.endpage862
dc.identifier.issn2574173X
dc.identifier.issue4
dc.identifier.pmid39394934
dc.identifier.scopus2-s2.0-85205966612
dc.identifier.scopusqualityQ2
dc.identifier.startpage857
dc.identifier.urihttps://doi.org/10.1002/npr2.12489
dc.identifier.urihttps://hdl.handle.net/11454/117124
dc.identifier.volume44
dc.identifier.wosWOS:001330137300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSungur, Ibrahim
dc.institutionauthorKeskin, Kaan
dc.institutionauthorAktas, Elif Ozge
dc.institutionauthorEker, Mehmet Cagdas
dc.institutionauthorid0000-0003-2116-3952
dc.institutionauthorid0000-0002-0505-1662
dc.institutionauthorid0000-0001-5496-9587
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofNeuropsychopharmacology Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectantipsychotics
dc.subjectaripiprazole
dc.subjectbipolar disorder
dc.titleExploring the efficacy and tolerability of two-injection start regimen of long-acting aripiprazole: A descriptive case series analysis
dc.typeArticle

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