Genetic Factors that Influence Short-term Neurodevelopmental Outcome in Term Hypoxic-Ischaemic Encephalopathic Neonates

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dc.contributor.authorCalkavur, S.
dc.contributor.authorAkisu, M.
dc.contributor.authorOlukman, O.
dc.contributor.authorBalim, Z.
dc.contributor.authorBerdeli, A.
dc.contributor.authorCakmak, B.
dc.contributor.authorKoroglu, O.
dc.contributor.authorYalaz, M.
dc.contributor.authorKultursay, N.
dc.date.accessioned2019-10-27T21:36:20Z
dc.date.available2019-10-27T21:36:20Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractIt is difficult to predict outcome in neonates that experience perinatal hypoxic ischaemia. Morbidity and mortality may be affected by genetic factors that augment inflammatory and coagulative responses. This prospective study analysed the effects of proinflammatory cytokine gene polymorphisms (tumour necrosis factor-alpha [TNFA] 308G>A and interleukin-6 [IL6] 174G>C) and prothrombotic factor gene mutations (prothrombin G20210A, factor V Leiden G1691A and methylenetetrahydrofolate reductase [MTHFR] C677T) on the early neurological prognosis in 40 term hypoxic ischaemic encephalopathic neonates. There were significant relationships for Sarnat and Sarnat staging with electroencephalographic findings, transfontanelle ultrasound (US) results, early neonatal outcome and neurological morbidity. Genetic mutations in the prothrombotic proteins, the TNFA 308G>A polymorphism and the cerebrospinal fluid levels of TNF-alpha protein were not related to clinical stage, electroencephalography, transfontanelle US or neurological status at discharge or at postnatal months 6 and 12. The IL6 174GC genotype demonstrated a protective role, being significantly correlated with normal electroencephalography, transfontanelle US and normal neurological findings at discharge. In conclusion, the IL6 174GC gene polymorphism seems to play a role in determining the risk and/or severity of perinatal cerebral injury.en_US
dc.identifier.doi10.1177/147323001103900517en_US
dc.identifier.endpage1756en_US
dc.identifier.issn0300-0605
dc.identifier.issn1473-2300
dc.identifier.issue5en_US
dc.identifier.pmid22117975en_US
dc.identifier.startpage1744en_US
dc.identifier.urihttps://doi.org/10.1177/147323001103900517
dc.identifier.urihttps://hdl.handle.net/11454/46037
dc.identifier.volume39en_US
dc.identifier.wosWOS:000297532400017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectASPHYXIAen_US
dc.subjectHYPOXIAen_US
dc.subjectENCEPHALOPATHIC NEWBORN INFANTSen_US
dc.subjectNEURODEVELOPMENTAL OUTCOMEen_US
dc.subjectGENEen_US
dc.subjectCYTOKINEen_US
dc.subjectTHROMBOPHILICen_US
dc.titleGenetic Factors that Influence Short-term Neurodevelopmental Outcome in Term Hypoxic-Ischaemic Encephalopathic Neonatesen_US
dc.typeArticleen_US

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