Polyacrylonitrile (PAN)/carbon nanotube (CNT) electrospun nanofibers: synthesis, characterization, their biocompatibility for L929 fibroblast cells and molecular docking studies

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dc.authorscopusid55487176600
dc.authorscopusid57212511655
dc.authorscopusid8973884700
dc.authorscopusid8684142100
dc.authorscopusid58777683800
dc.authorscopusid37007132600
dc.authorscopusid6701651517
dc.contributor.authorInce, Yardimci, A.
dc.contributor.authorMutlu, D.
dc.contributor.authorIstifli, E.S.
dc.contributor.authorArslan, S.
dc.contributor.authorMahaleh, S.P.G.
dc.contributor.authorYagmurcukardes, N.
dc.contributor.authorKara, P.
dc.date.accessioned2024-08-25T18:32:17Z
dc.date.available2024-08-25T18:32:17Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractThere has been an important interest in to use of electrospun nanomaterials for tissue engineering applications due to the excellent scaffold-cell interaction provided by high interconnectivity and high porosity by electrospun nanofibers. In this study, Polyacrylonitrile (PAN) and carbon nanotube-inserted PAN (PAN/CNT) nanofibers were produced by the electrospinning method and characterized by SEM, FT-IR, and EIS spectroscopy. Both PAN and PAN/CNT nanofibers were obtained beadless and ordered with the average fiber diameters of 277.61 ± 43.6 and 171.01 ± 48.4, respectively. The influence of CNT addition on PAN nanofibers was observed with the decrease of diameter and increase of electrical conductivity of nanofibers. Then, the biocompatibility of PAN and PAN/CNT nanofibers was evaluated by the MTT and AO/EB double-staining experiments. It was observed that the nanofibers showed no cytotoxic effect on L929 fibroblast cells. In the docking experiments, while both PAN and PAN/CNT showed energetically favorable interactions (?G = ?4.60 kcal/mol; ?7.26 kcal/mol, respectively) with the membrane bilayer complex, PAN/CNT formed a more stable binding with the cellular membrane compared to PAN alone. Docking results mechanistically support the more effective increase in the proliferation of L929 fibroblasts at high concentrations in vitro, as PAN/CNT exhibits stronger binding affinity and interaction with the cellular membrane. The increase in electrical conductivity of nanofibers influenced the proliferation positively, as well. © 2023 Taylor & Francis Group, LLC.en_US
dc.identifier.doi10.1080/00914037.2023.2297413
dc.identifier.issn0091-4037
dc.identifier.scopus2-s2.0-85180512253en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/00914037.2023.2297413
dc.identifier.urihttps://hdl.handle.net/11454/100192
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofInternational Journal of Polymeric Materials and Polymeric Biomaterialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectcarbon nanotube (CNT)en_US
dc.subjectElectrospinningen_US
dc.subjectL929 fibroblast cellsen_US
dc.subjectmolecular dockingen_US
dc.subjectnanofiberen_US
dc.subjectpolyacrylonitrile (PAN)en_US
dc.subjecttissue engineeringen_US
dc.subjectBinding energyen_US
dc.subjectBiocompatibilityen_US
dc.subjectCell cultureen_US
dc.subjectCell engineeringen_US
dc.subjectElectric conductivityen_US
dc.subjectElectrospinningen_US
dc.subjectFibroblastsen_US
dc.subjectMolecular modelingen_US
dc.subjectNanofibersen_US
dc.subjectScaffolds (biology)en_US
dc.subjectTissueen_US
dc.subjectCarbon nanotubeen_US
dc.subjectElectrical conductivityen_US
dc.subjectElectrospun nanofibersen_US
dc.subjectFibroblast cellsen_US
dc.subjectL929 fibroblast cellen_US
dc.subjectL929 fibroblastsen_US
dc.subjectMolecular dockingen_US
dc.subjectPolyacrylonitrileen_US
dc.subjectPolyacrylonitrile nanofibreen_US
dc.subjectTissues engineeringsen_US
dc.subjectCarbon nanotubesen_US
dc.titlePolyacrylonitrile (PAN)/carbon nanotube (CNT) electrospun nanofibers: synthesis, characterization, their biocompatibility for L929 fibroblast cells and molecular docking studiesen_US
dc.typeArticleen_US

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