Effect of adenine on bacterial translocation using technetium-99m labeled E. coli in an intestinal obstruction model in rats

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dc.contributor.authorOflaz, Ugur
dc.contributor.authorLambrecht, Fatma Yurt
dc.contributor.authorYilmaz, Osman
dc.contributor.authorPekcetin, Cetin
dc.date.accessioned2019-10-27T21:42:00Z
dc.date.available2019-10-27T21:42:00Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractThis study aims to investigate effects of adenine on bacterial translocation (BT) using Tc-99m-labeled E. coli in an intestinal obstruction rat model. In the study twenty-one rats were used. The rats were divided into three groups according to different feeding patterns. The control group (CG) was fed with a standard chow diet for 7 days. Group A1 and group A2 were fed with adenine supplemented chow diet for 7 days. At the end of the feeding period, after all groups was submitted intestinal obstruction. Tc-99m-E. coli was injected into the rats' terminal ileum under anesthetic. The rats were sacrificed under aseptic conditions at 24th h after the surgery. The uptake of Tc-99m-E. coli was determined in organs such as the liver, mesenteric lymph nodes, spleen and ileum. Group A1 and group A2 results show that the uptake of Tc-99m-E. coli decreased in the blood and organs comparing to the CG. As a result, it was observed that adenine reduced the level of BT when compared with CG. The beneficial effect of adenine on BT in intestinal obstruction was observed. However, further studies are needed to more clearly assess how this benefit can be achieved.en_US
dc.identifier.doi10.1007/s10967-012-2223-y
dc.identifier.endpage964en_US
dc.identifier.issn0236-5731
dc.identifier.issn1588-2780
dc.identifier.issn0236-5731en_US
dc.identifier.issn1588-2780en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage959en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-012-2223-y
dc.identifier.urihttps://hdl.handle.net/11454/46798
dc.identifier.volume295en_US
dc.identifier.wosWOS:000313713300022en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBacterial translocationen_US
dc.subjectIntestinal obstructionen_US
dc.subjectAdenineen_US
dc.subjectImmune systemen_US
dc.subjectNucleotideen_US
dc.subjectTc-99m-E. colien_US
dc.titleEffect of adenine on bacterial translocation using technetium-99m labeled E. coli in an intestinal obstruction model in ratsen_US
dc.typeArticleen_US

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