Effect of adenine on bacterial translocation using technetium-99m labeled E. coli in an intestinal obstruction model in rats
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study aims to investigate effects of adenine on bacterial translocation (BT) using Tc-99m-labeled E. coli in an intestinal obstruction rat model. In the study twenty-one rats were used. The rats were divided into three groups according to different feeding patterns. The control group (CG) was fed with a standard chow diet for 7 days. Group A1 and group A2 were fed with adenine supplemented chow diet for 7 days. At the end of the feeding period, after all groups was submitted intestinal obstruction. Tc-99m-E. coli was injected into the rats' terminal ileum under anesthetic. The rats were sacrificed under aseptic conditions at 24th h after the surgery. The uptake of Tc-99m-E. coli was determined in organs such as the liver, mesenteric lymph nodes, spleen and ileum. Group A1 and group A2 results show that the uptake of Tc-99m-E. coli decreased in the blood and organs comparing to the CG. As a result, it was observed that adenine reduced the level of BT when compared with CG. The beneficial effect of adenine on BT in intestinal obstruction was observed. However, further studies are needed to more clearly assess how this benefit can be achieved.
Açıklama
Anahtar Kelimeler
Bacterial translocation, Intestinal obstruction, Adenine, Immune system, Nucleotide, Tc-99m-E. coli
Kaynak
Journal of Radioanalytical and Nuclear Chemistry
WoS Q Değeri
Q1
Scopus Q Değeri
Q2
Cilt
295
Sayı
2
