A case of chronic hepatitis B with primary adefovir resistance

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dc.contributor.authorYamazhan, Tansu
dc.contributor.authorSertoz, Ruchan
dc.contributor.authorPullukcu, Husnu
dc.contributor.authorTasbakan, Meltem
dc.contributor.authorUlusoy, Sercan
dc.contributor.authorErensoy, Selda
dc.date.accessioned2019-10-27T19:35:21Z
dc.date.available2019-10-27T19:35:21Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractImplementation of antiviral therapy leads to the emergence of mutant strains during the treatment in chronic hepatitis B. Hepatitis 6 virus (HBV) with primary antiviral resistance may be rarely encountered. In this report, a chronic hepatitis B case who had never received adefovir dipivoxil but had primary adefovir resistance, was presented. HBeAg positive 25-year-old male patient was treated with interferon (IFN)alpha (thrice a week 10 MU) and lamivudine (100 mg/daily) combination for one year. At the end of this treatment although HBV-DNA was under the detectable limit and ALT levels returned to normal, anti-HBe antibodies did not develop. During the course of lamivudin treatment on the third year virus was found to be resistant to lamivudin [FLM+YMDD+YIDD+YVDD (Inno-LiPA HBV DR, Innogenetics Ghent, Belgium)] and adefovir was added to the lamivudin therapy. At the end of eight months of combination therapy, ALT levels did not return to normal and HBV-DNA was still in detectable levels. On the 11(th) month resistance to adefovir was analysed and rtA181T mutation was found by DNA sequence analysis (Big Dye Terminator Cycle Sequencing kit, Applied Biosystems, USA). Since there had been no response to adefovir from the initiation of the therapy, primary adefovir resistance was suspected. Primary adefovir resistance was confirmed by the detection of the same mutation in pre-adefovir treatment serum sample of the patient. Lamivudin was re-added to the therapy, however, HBV-DNA still remained positive on the third month of this combination therapy. The patient got out of routine follow-up after this period.en_US
dc.identifier.endpage301en_US
dc.identifier.issn0374-9096
dc.identifier.issue2en_US
dc.identifier.pmid17682718en_US
dc.identifier.startpage297en_US
dc.identifier.urihttps://hdl.handle.net/11454/39730
dc.identifier.volume41en_US
dc.identifier.wosWOS:000246913000017en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherAnkara Microbiology Socen_US
dc.relation.ispartofMikrobiyoloji Bultenien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthepatitis Ben_US
dc.subjectadefoviren_US
dc.subjectprimary resistanceen_US
dc.titleA case of chronic hepatitis B with primary adefovir resistanceen_US
dc.typeArticleen_US

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