Hematopoietic Stem Cell Transplantation Using Preimplantation Genetic Diagnosis and Human Leukocyte Antigen Typing for Human Leukocyte Antigen-Matched Sibling Donor: A Turkish Multicenter Study

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dc.contributor.authorKurekci, Emin
dc.contributor.authorKupesiz, Alphan
dc.contributor.authorAnak, Sema
dc.contributor.authorOzturk, Gulyuz
dc.contributor.authorGursel, Orhan
dc.contributor.authorAksoylar, Serap
dc.contributor.authorIleri, Talia
dc.contributor.authorKuskonmaz, Baris
dc.contributor.authorEker, Ibrahim
dc.contributor.authorCetin, Mualla
dc.contributor.authorKarasu, Gulsun Tezcan
dc.contributor.authorKaya, Zuhre
dc.contributor.authorFisgin, Tunc
dc.contributor.authorErtem, Mehmet
dc.contributor.authorKansoy, Savas
dc.contributor.authorYesilipek, Mehmet Akif
dc.date.accessioned2019-10-27T11:08:21Z
dc.date.available2019-10-27T11:08:21Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractPreimplantation genetic diagnosis involves the diagnosis of a genetic disorder in embryos obtained through in vitro fertilization, selection of healthy embryos, and transfer of the embryos to the mother's uterus. Preimplantation genetic diagnosis has been used not only to avoid the risk of having an affected child, but it also offers, using HLA matching, preselection of potential HLA-genoidentical healthy donor progeny for an affected sibling who requires bone marrow transplantation. Here, we share the hematopoietic stem cell transplantation results of 52 patients with different benign and malign hematological or metabolic diseases or immunodeficiencies whose donors were siblings born with this technique in Turkey since 2008. The median age of the patients' at the time of the transplantation was 8 years (range, 3 to 16 years) and the median age of the donors was 2 years (range,.5 to 6 years). The most common indication for HSCT was thalassemia major (42 of all patients, 80%). The stem cell source in all of the transplantations was bone marrow. In 37 of the transplantations, umbiliCal cord blood of the same donor was also used. In 50 of the 52 patients, full engraftment was achieved with a mean of 4.6 x 10(6) CD 34(+) cells per kg of recipient weight. Ninety-six percent of the patients have been cured through hematopoietic stem cell transplantation without any complication. Primary engraftment failure was seen in only 2 patients with thalassemia major. All of the donors and the patients are alive with good health status. Preimplantation genetic diagnosis with HLA matching offers a life-saving chance for patients who need transplantation but lack an HLA genoidentical donor. (C) 2017 American Society for Blood and Marrow Transplantation.en_US
dc.identifier.doi10.1016/j.bbmt.2017.02.002en_US
dc.identifier.endpage794en_US
dc.identifier.issn1083-8791
dc.identifier.issn1523-6536
dc.identifier.issue5en_US
dc.identifier.pmid28192253en_US
dc.identifier.startpage790en_US
dc.identifier.urihttps://doi.org/10.1016/j.bbmt.2017.02.002
dc.identifier.urihttps://hdl.handle.net/11454/32157
dc.identifier.volume23en_US
dc.identifier.wosWOS:000400127500011en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofBiology of Blood and Marrow Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPreimplantation genetic diagnosisen_US
dc.subjectHLA matchingen_US
dc.subjectTransplantationen_US
dc.subjectChildrenen_US
dc.titleHematopoietic Stem Cell Transplantation Using Preimplantation Genetic Diagnosis and Human Leukocyte Antigen Typing for Human Leukocyte Antigen-Matched Sibling Donor: A Turkish Multicenter Studyen_US
dc.typeArticleen_US

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