Exenatide improves ovarian and endometrial injury and preserves ovarian reserve in streptozocin induced diabetic rats

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dc.contributor.authorArtunc-Ulkumen, Burcu
dc.contributor.authorPala, Halil Gursoy
dc.contributor.authorPala, Emel Ebru
dc.contributor.authorYavasoglu, Altug
dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorErbas, Oytun
dc.date.accessioned2019-10-27T22:27:39Z
dc.date.available2019-10-27T22:27:39Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractWe aimed to evaluate: (1) endometrial and ovarian tissue injury caused by the glucose toxicity in diabetic rat model and (2) the effect of GLP-1 analog (exenatide) on endometrial and ovarian diabetes induced injury with emphasizing the underlying mechanism. The study group composed of 24 female rats assigned randomly into 3 groups. Group 1 was the control group (n = 8) and received no treatment. Diabetes was induced by intraperitoneal injection of streptozocin for 16 rats which are further assigned randomly into 2 groups: 1 ml/kg intraperitoneal saline was given to Group-2 (diabetic non-treated control group, 8 rats) and 10 mu g/kg/day of intraperitoneal exenatide was given to Group 3 (exenatide treated group, 8 rats) for four weeks. After four weeks, blood samples were collected and hysterectomy with bilateral oophorectomy was performed for histopathological examination. Diabetes caused endometrial and ovarian tissue injury in rats (p < 0.0001). Serum transforming growth factor beta (TGF-beta), malonylaldehyde (MDA), pentraxin-3 (PTX-3) levels were higher in diabetic rats (p < 0.0001), whereas antimullerian hormone (AMH) was lower (p < 0.001). Serum levels of these markers reflected that Diabetes induced injury in the reproductive tract occured via oxidative stress, fibrosis and severe inflammation. Diabetes diminished ovarian reserve. Exenatide treatment improved the histological degeneration and fibrosis in the endometrium and ovary with concomitant decrease in inflammatory and oxidative stress markers (p < 0.05). Exenatide also improved ovarian reserve (p < 0.05). Glucose toxicity occured severely in ovary and endometrium in DM. After exenatide treatment; ovarian and endometrial injury and fibrosis seems to decrease significantly. The effects of exenatide in rat models give hope to prevent the women with DM from premature ovarian failure and endometrial dysfunction.en_US
dc.identifier.doi10.3109/09513590.2014.975686en_US
dc.identifier.endpage201en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue3en_US
dc.identifier.pmid25366063en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage196en_US
dc.identifier.urihttps://doi.org/10.3109/09513590.2014.975686
dc.identifier.urihttps://hdl.handle.net/11454/50733
dc.identifier.volume31en_US
dc.identifier.wosWOS:000358467100006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti mullerian hormoneen_US
dc.subjectdiabetes mellitusen_US
dc.subjectendometrial dysfunctionen_US
dc.subjectexenatideen_US
dc.subjectglucagone like peptide-1 (GLP-1) analogueen_US
dc.subjectovarian injuryen_US
dc.subjectoxidative stressen_US
dc.subjectpentraxine-3en_US
dc.titleExenatide improves ovarian and endometrial injury and preserves ovarian reserve in streptozocin induced diabetic ratsen_US
dc.typeArticleen_US

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