Clinical Features of Pediatric Age Herpes Simplex Virus Keratitis

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dc.authoridAkbas Ulman, Elif/0000-0002-3193-0572
dc.authoridPalamar, Melis/0000-0002-2494-0131
dc.authorscopusid58481451500
dc.authorscopusid24077472700
dc.authorscopusid56146785900
dc.authorscopusid23989747000
dc.authorwosidAkbas Ulman, Elif/HHZ-0354-2022
dc.authorwosidPalamar, Melis/H-5903-2013
dc.contributor.authorAkbaş Ulman, Elif
dc.contributor.authorBarut Selver, Özlem
dc.contributor.authorDemirkılınç Biler, Elif
dc.contributor.authorPalamar, Melis
dc.date.accessioned2024-08-25T18:35:49Z
dc.date.available2024-08-25T18:35:49Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose:The objective of this study is to evaluate the clinical features of pediatric herpes simplex virus keratitis, its recurrence rates, and its effects on visual acuity. Methods:In this retrospective case series, records of pediatric patients (0-16 years) who presented with herpes simplex virus keratitis between January 2012 and September 2021 were evaluated. Data including age, gender, additional systemic diseases, the number of recurrences, recurrence time, treatment protocol, follow-up period, and presence of amblyopia were reviewed. Results:Twenty-four patients (16 females and 8 males) with a mean age of 6.6 & PLUSMN; 4 (1.1-15) years were included in the study. The mean follow-up time was 21 & PLUSMN; 19.9 (7-94) months. Four patients (16.6%) had bilateral keratitis. Including all 4 patients with bilateral involvement, a total of 10 (41.6%) patients had additional systemic diseases that cause immunodeficiency. After prophylactic antiviral treatment for at least 6 months (except for isolated epithelial keratitis), recurrence was detected in 5 (22.7%) patients, who were all immunodeficient. Among immunodeficient individuals, the recurrence rate was found to be 50%. Keratitis recurrence was significantly associated with immunodeficiency (P = 0.03). However, type of keratitis (P = 0.42), gender (P = 0.47), and bilaterality (P = 0.54) were not related with recurrence. 66.7% of the patients younger than 10 years developed amblyopia during follow-up. Conclusions:In childhood, the most frequent corneal manifestation of herpes simplex virus is stromal keratitis that mostly progresses with corneal scarring, residual astigmatism, and amblyopia. The recurrence rate increases in the presence of immunosuppression. Close follow-up, rapid diagnosis, and treatment are critical for battling against amblyopia and achieving good visual prognosis.en_US
dc.identifier.doi10.1097/ICO.0000000000003264
dc.identifier.endpage1103en_US
dc.identifier.issn0277-3740
dc.identifier.issn1536-4798
dc.identifier.issue9en_US
dc.identifier.pmid36921273en_US
dc.identifier.scopus2-s2.0-85166474178en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1099en_US
dc.identifier.urihttps://doi.org/10.1097/ICO.0000000000003264
dc.identifier.urihttps://hdl.handle.net/11454/100420
dc.identifier.volume42en_US
dc.identifier.wosWOS:001042110400007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCorneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectherpes simplexen_US
dc.subjectkeratitisen_US
dc.subjectchilden_US
dc.subjectamblyopiaen_US
dc.subjectpediatricen_US
dc.subjectAnterior Segmenten_US
dc.subjectInfectionen_US
dc.subjectStrabismusen_US
dc.subjectPrevalenceen_US
dc.subjectManagementen_US
dc.subjectAmblyopiaen_US
dc.subjectDiseaseen_US
dc.titleClinical Features of Pediatric Age Herpes Simplex Virus Keratitisen_US
dc.typeArticleen_US

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