Convulsive status epilepticus in children: Etiology, treatment protocol and outcome

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dc.contributor.authorSaz, Eylem Ulas
dc.contributor.authorKarapinar, Bulent
dc.contributor.authorOzcetin, Mustafa
dc.contributor.authorPolat, Muzaffer
dc.contributor.authorTosun, Ayse
dc.contributor.authorSerdaroglu, Gul
dc.contributor.authorGokben, Sarenur
dc.contributor.authorTekgul, Hasan
dc.date.accessioned2019-10-27T21:24:50Z
dc.date.available2019-10-27T21:24:50Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractThis study aimed to determine the etiology, treatment protocol and outcome of convulsive status epilepticus (SE) in children. An institutional treatment protocol using benzodiazepines (diazepam and midazolam) was assessed in a retrospective case study. The treatment protocol (Ege Pediatric Status Epilepticus Protocol or EPSEP) was developed based on an operational definition of pediatric SE according to the duration of seizure activity. Pediatric SE is divided into three categories: initial SE (20-30 min), established SE (30-60 min) and refractory SE (>60 min). Eight (30%) of the studied episodes were initial SE, 10 (37%) were established SE, and 9 (33%) were refractory SE. With respect to the etiological spectrum of SE, 11(40%) children had meningitis or encephalitis. Febrile SE was identified in 7 (26%) patients. Only 2 episodes of initial SE (7.5%) were controlled with first step of the protocol (two concomitant-doses of rectal diazepam). Midazolam bolus and infusions (up to 1.2 mu g/kg/min) were used to treat 22 episodes of SE (9 refractory SE, 10 established SE and 3 initial SE). Complete arrest of convulsive SE was achieved in 21 of 22 (95%) episodes with midazolam infusion. We concluded that the combined use of benzodiazepines (diazepam + midazolam) was safe and effective in the treatment of convulsive SE in children. (C) 2010 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.seizure.2010.10.034en_US
dc.identifier.endpage118en_US
dc.identifier.issn1059-1311
dc.identifier.issn1532-2688
dc.identifier.issue2en_US
dc.identifier.pmid21195636en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage115en_US
dc.identifier.urihttps://doi.org/10.1016/j.seizure.2010.10.034
dc.identifier.urihttps://hdl.handle.net/11454/44674
dc.identifier.volume20en_US
dc.identifier.wosWOS:000288294900004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co Ltden_US
dc.relation.ispartofSeizure-European Journal of Epilepsyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectProtocolen_US
dc.subjectEfficacyen_US
dc.subjectMidazolamen_US
dc.subjectChildrenen_US
dc.subjectOutcomeen_US
dc.subjectStatus epilepticusen_US
dc.titleConvulsive status epilepticus in children: Etiology, treatment protocol and outcomeen_US
dc.typeArticleen_US

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