Mycobacterial disease in patients with chronic granulomatous disease: A retrospective analysis of 71 cases

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dc.contributor.authorConti, Francesca
dc.contributor.authorOswaldo Lugo-Reyes, Saul
dc.contributor.authorBlancas Galicia, Lizbeth
dc.contributor.authorHe, Jianxin
dc.contributor.authorAksu, Guzide
dc.contributor.authorde Oliveira, Edgar Borges, Jr.
dc.contributor.authorDeswarte, Caroline
dc.contributor.authorHubeau, Marjorie
dc.contributor.authorKaraca, Neslihan
dc.contributor.authorde Suremain, Maylis
dc.contributor.authorGuerin, Antoine
dc.contributor.authorBaba, Laila Ait
dc.contributor.authorPrando, Carolina
dc.contributor.authorGuerrero, Gloria G.
dc.contributor.authorEmiroglu, Melike
dc.contributor.authorOz, Fatma Nur
dc.contributor.authorYamazaki Nakashimada, Marco Antonio
dc.contributor.authorGonzalez Serrano, Edith
dc.contributor.authorEspinosa, Sara
dc.contributor.authorBarlan, Isil
dc.contributor.authorPerez, Nestor
dc.contributor.authorRegairaz, Lorena
dc.contributor.authorGuidos Morales, Hector Eduardo
dc.contributor.authorBezrodnik, Liliana
dc.contributor.authorDi Giovanni, Daniela
dc.contributor.authorDbaibo, Ghassan
dc.contributor.authorAilal, Fatima
dc.contributor.authorGalicchio, Miguel
dc.contributor.authorOleastro, Matias
dc.contributor.authorChemli, Jalel
dc.contributor.authorDanielian, Silvia
dc.contributor.authorPerez, Laura
dc.contributor.authorClaudia Ortega, Maria
dc.contributor.authorSoto Lavin, Susana
dc.contributor.authorHertecant, Joseph
dc.contributor.authorAnal, Ozden
dc.contributor.authorKechout, Nadia
dc.contributor.authorAl-Idrissi, Eman
dc.contributor.authorElGhazali, Gehad
dc.contributor.authorBondarenko, Anastasia
dc.contributor.authorChernyshova, Liudmyla
dc.contributor.authorCiznar, Peter
dc.contributor.authorHerbigneaux, Rose-Marie
dc.contributor.authorDiabate, Aminata
dc.contributor.authorNdaga, Stephanie
dc.contributor.authorKonte, Barik
dc.contributor.authorCzarna, Ambre
dc.contributor.authorMigaud, Melanie
dc.contributor.authorPedraza-Sanchez, Sigifredo
dc.contributor.authorBano Zaidi, Mussaret
dc.contributor.authorVogt, Guillaume
dc.contributor.authorBlanche, Stephane
dc.contributor.authorBenmustapha, Imen
dc.contributor.authorMansouri, Davood
dc.contributor.authorAbel, Laurent
dc.contributor.authorBoisson-Dupuis, Stephanie
dc.contributor.authorMahlaoui, Nizar
dc.contributor.authorBousfiha, Ahmed Aziz
dc.contributor.authorPicard, Capucine
dc.contributor.authorBarbouche, Ridha
dc.contributor.authorAl-Muhsen, Saleh
dc.contributor.authorEspinosa-Rosales, Francisco J.
dc.contributor.authorKutukculer, Necil
dc.contributor.authorCondino-Neto, Antonio
dc.contributor.authorCasanova, Jean-Laurent
dc.contributor.authorBustamante, Jacinta
dc.date.accessioned2019-10-27T23:09:23Z
dc.date.available2019-10-27T23:09:23Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Chronic granulomatous disease (CGD) is a rare primary immunodeficiency caused by inborn errors of the phagocyte nicotinamide adenine dinucleotide phosphate oxidase complex. From the first year of life onward, most affected patients display multiple, severe, and recurrent infections caused by bacteria and fungi. Mycobacterial infections have also been reported in some patients. Objective: Our objective was to assess the effect of mycobacterial disease in patients with CGD. Methods: We analyzed retrospectively the clinical features of mycobacterial disease in 71 patients with CGD. Tuberculosis and BCG disease were diagnosed on the basis of microbiological, pathological, and/or clinical criteria. Results: Thirty-one (44%) patients had tuberculosis, and 53 (75%) presented with adverse effects of BCG vaccination; 13 (18%) had both tuberculosis and BCG infections. None of these patients displayed clinical disease caused by environmental mycobacteria, Mycobacterium leprae, or Mycobacterium ulcerans. Most patients (76%) also had other pyogenic and fungal infections, but 24% presented solely with mycobacterial disease. Most patients presented a single localized episode of mycobacterial disease (37%), but recurrence (18%), disseminated disease (27%), and even death (18%) were also observed. One common feature in these patients was an early age at presentation for BCG disease. Mycobacterial disease was the first clinical manifestation of CGD in 60% of these patients. Conclusion: Mycobacterial disease is relatively common in patients with CGD living in countries in which tuberculosis is endemic, BCG vaccine is mandatory, or both. Adverse reactions to BCG and severe forms of tuberculosis should lead to a suspicion of CGD. BCG vaccine is contraindicated in patients with CGD.en_US
dc.description.sponsorshipDepartment of Public Health and Cellular Biology, University of Rome Tor Vergata; French National Research Agency (ANR)French National Research Agency (ANR); INSERMInstitut National de la Sante et de la Recherche Medicale (Inserm); University Paris Descartes; Rockefeller University; St Giles Foundation; French National Research Agency (ANR) under the "Investments for the Future" programFrench National Research Agency (ANR) [ANR-10-IAHU-01]; French National Research Agency (ANR) under the grant IFNGPHOXFrench National Research Agency (ANR) [ANR13-ISV3-0001-01]; Fundacao de Amparoa Pesquisa do Estado de So Paulo (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2012/11757-2, 2010/51814-0, 2012/51094-2]; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)National Council for Scientific and Technological Development (CNPq) [303809/2010-8]; Consejo Nacional de Ciencia y Tecnologia (CONACYT)Consejo Nacional de Ciencia y Tecnologia (CONACyT) [182817]en_US
dc.description.sponsorshipF.C. was supported by the Department of Public Health and Cellular Biology, University of Rome Tor Vergata. A.G. was supported by the French National Research Agency (ANR). The Laboratory of Human Genetics of Infectious Diseases is supported by institutional grants from INSERM, University Paris Descartes, the Rockefeller University, and the St Giles Foundation and grants from the French National Research Agency (ANR) under the "Investments for the Future" program (grant no. ANR-10-IAHU-01) and grant IFNGPHOX (no. ANR13-ISV3-0001-01). E.B.d.O. and A.C.-N. are supported by Fundacao de Amparoa Pesquisa do Estado de So Paulo (FAPESP grants 2012/11757-2, 2010/51814-0, and 2012/51094-2) and Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ grant 303809/2010-8). S.P.-S. is supported by Consejo Nacional de Ciencia y Tecnologia (CONACYT, grant 182817).en_US
dc.identifier.doi10.1016/j.jaci.2015.11.041en_US
dc.identifier.endpage+en_US
dc.identifier.issn0091-6749
dc.identifier.issn1097-6825
dc.identifier.issue1en_US
dc.identifier.pmid26936803en_US
dc.identifier.startpage241en_US
dc.identifier.urihttps://doi.org/10.1016/j.jaci.2015.11.041
dc.identifier.urihttps://hdl.handle.net/11454/52627
dc.identifier.volume138en_US
dc.identifier.wosWOS:000379659100026en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMosby-Elsevieren_US
dc.relation.ispartofJournal of Allergy and Clinical Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMycobacteriaen_US
dc.subjectBCGen_US
dc.subjectchronic granulomatous diseaseen_US
dc.subjecttuberculosisen_US
dc.subjectprimary immunodeficiencyen_US
dc.titleMycobacterial disease in patients with chronic granulomatous disease: A retrospective analysis of 71 casesen_US
dc.typeArticleen_US

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