Clinicopathologic and Genetic Characterization of Follicular Lymphomas Presenting in the Ovary Reveals 2 Distinct Subgroups

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dc.contributor.authorOzsan, Nazan
dc.contributor.authorBedke, Brent J.
dc.contributor.authorLaw, Mark E.
dc.contributor.authorInwards, David J.
dc.contributor.authorKetterling, Rhett P.
dc.contributor.authorKnudson, Ryan A.
dc.contributor.authorKeeney, Gary L.
dc.contributor.authorDogan, Ahmet
dc.contributor.authorFeldman, Andrew L.
dc.date.accessioned2019-10-27T21:35:37Z
dc.date.available2019-10-27T21:35:37Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractMost lymphomas arising in the ovary are diffuse large B-cell or Burkitt lymphomas. Follicular lymphomas of the ovary are rare, and their clinicopathologic features are incompletely understood. We investigated clinical, morphologic, immuno-phenotypic, and genetic features of follicular lymphomas initially diagnosed in the ovary in 16 women. We performed immunohistochemistry for CD20, CD3, CD10, BCL6, IRF4/MUM1, and BCL2 and interphase fluorescence in situ hybridization for translocations involving BCL2, BCL6, and IRF4. Clustering was performed on the basis of clinicopathologic and genetic variables using Cluster 3.0. Ages ranged from 42 to 73 years. Unsupervised hierarchical clustering analysis revealed 2 distinct groups of patients. One group (group A) included 7 cases, which were negative or weakly positive for BCL2 protein and lacked IGH@/BCL2 translocations (6 cases evaluable). Four patients were of grade 3A, and 3 patients were of grade 2. Four had stage IE disease with unilateral ovarian involvement (subgroup A(1)), and the stage was unknown in 3 patients (subgroup A(2)). The second group (group B) included 9 cases of low histologic grade, which strongly expressed BCL2 protein and had IGH@/BCL2 translocations (7 cases evaluable). Six patients had stage III/IV disease, 2 had stage II disease, and the stage was unknown in 1 patient. Although follow-up intervals were limited, patients with higher-grade/ low-stage disease tended to have favorable outcomes. These data indicate 2 distinct types of follicular lymphomas presenting in the ovary: a low-grade/high-stage/BCL2-positive group and a higher-grade/low-stage/BCL2-negative group. This latter group likely has distinct biological and immunologic characteristics, as has been suggested for higher-grade/ low-stage follicular lymphomas presenting at other extranodal sites.en_US
dc.description.sponsorshipDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MNen_US
dc.description.sponsorshipSupported in part by the Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN. The findings were presented in part at the XVth Meeting of the European Association for Haematopathology, Uppsala, Sweden, 2010. The authors have disclosed that they have no significant relationship with, or financial interest in, any commercial companies pertaining to this article.en_US
dc.identifier.doi10.1097/PAS.0b013e31822bd8a8en_US
dc.identifier.endpage1699en_US
dc.identifier.issn0147-5185
dc.identifier.issn1532-0979
dc.identifier.issue11en_US
dc.identifier.pmid21997689en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1691en_US
dc.identifier.urihttps://doi.org/10.1097/PAS.0b013e31822bd8a8
dc.identifier.urihttps://hdl.handle.net/11454/45898
dc.identifier.volume35en_US
dc.identifier.wosWOS:000296569500010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAmerican Journal of Surgical Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectovaryen_US
dc.subjectfollicular lymphomaen_US
dc.subjectextranodal lymphomaen_US
dc.titleClinicopathologic and Genetic Characterization of Follicular Lymphomas Presenting in the Ovary Reveals 2 Distinct Subgroupsen_US
dc.typeArticleen_US

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