Changes in retinal microvasculature and serum Gremlin-1 levels in acromegaly: A case-control study

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dc.authorid0000-0002-1849-3179
dc.authorid0000-0001-6929-6645
dc.authorid0000-0002-8268-536X
dc.authorid0000-0003-1809-2655
dc.authorid0000-0003-3616-8051
dc.authorid0000-0002-6801-8499
dc.authorid0000-0001-6359-1600
dc.contributor.authorUnal Kocabas, Gokcen
dc.contributor.authorFurundaoturan, Onur
dc.contributor.authorDegirmenci, Cumali
dc.contributor.authorOzgur, Su
dc.contributor.authorKocamanoglu, Meltem
dc.contributor.authorArslan, Cigdem Gozde
dc.contributor.authorSarer Yurekli, Banu
dc.contributor.authorPehlivan Koroglu, Esma
dc.contributor.authorAfrashi, Filiz
dc.contributor.authorYildirim Simsir, Ilgin
dc.date.accessioned2025-02-25T11:59:15Z
dc.date.available2025-02-25T11:59:15Z
dc.date.issued2024
dc.departmentEge Üniversitesi, Tıp Fakültesi, Dahili Bilimler Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: There are controversial results about the effects of GH/IGF-1 on retinal vasculature. Gremlin-1 has roles in both pituitary tumorigenesis and angiogenesis. Therefore, we aimed to detect retinal micro-vascular changes in acromegaly with OCTA and examine its association with serum Gremlin-1 levels. Design: A cross-sectional, case-control study Methods: We included 53 acromegaly patients and age/gender-matched 31 healthy controls. To evaluate retinal structure, optical coherence tomography angiography (OCTA) imaging was performed. Gremlin -1 levels were measured by the ELISA method. Results: Acromegaly patients had significantly lower superficial total density (p < 0.001), superficial parafoveal density (p = 0.002), superficial perifoveal density (p < 0.001); deep total density (p < 0.001), deep parafoveal density (p < 0.001), deep perifoveal density (p < 0.001). Total thickness and perifoveal thickness were significantly lower in the acromegaly group. Gremlin-1 levels were significantly lower in acromegaly patients (1.22(0.13) vs 1.38(0.29); p = 0.015, for acromegaly and control groups, respectively). We assessed study groups based on glucose tolerance status. Normal glucose tolerance (NGT) acromegaly patients had significantly lower superficial total density (p = 0.036), superficial perifoveal density (p = 0.003), deep total density (p = 0.023), and deep perifoveal density (p = 0.023) compared to NGT controls. According to backward linear regression analysis, the presence of acromegaly itself consistently showed a significant negative impact on all types of vascular density. Conclusion: Patients with acromegaly have decreased vascular density and lower levels of Gremlin-1 independent of glucose tolerance status. Acromegaly may cause a reduction in gremlin-1 as a compensatory mechanism due to high IGF-1 levels known as an angiogenic factor, which in turn leads to the decrease in vascular density, or gremlin-1 may already have shown a decline in response to chronic inflammation and endothelial dysfunction in acromegaly resulting in a reduction in vascular density.
dc.identifier.citationUnal Kocabas, G., Furundaoturan, O., Degırmencı, C., Ozgur, S., Kocamanoglu, M., Aslan, C. G., Pehlivan Koroglu, E., Afrashı, F., Akcay, Y., Yildirim Simsir, I., & Sarer Yurekli, B. (2024). Changes in retinal microvasculature and serum gremlin-1 levels in acromegaly: A case-control study. Photodiagnosis and Photodynamic Therapy, 50, 104415.
dc.identifier.doi10.1016/j.pdpdt.2024.104415
dc.identifier.endpage8
dc.identifier.issn1572-1000
dc.identifier.issueDec
dc.identifier.pmid39592020
dc.identifier.scopus2-s2.0-85210629612
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1016/j.pdpdt.2024.104415
dc.identifier.urihttps://hdl.handle.net/11454/116220
dc.identifier.volume50
dc.identifier.wosWOS:001374843200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUnal Kocabas, Gokcen
dc.institutionauthorFurundaoturan, Onur
dc.institutionauthorDegirmenci, Cumali
dc.institutionauthorArslan, Cigdem Gozde
dc.institutionauthorPehlivan Koroglu, Esma
dc.institutionauthorSarer Yurekli, Banu
dc.institutionauthorAfrashi, Filiz
dc.institutionauthorSimsir, Ilgin
dc.institutionauthorid0000-0002-1849-3179
dc.institutionauthorid0000-0001-6929-6645
dc.institutionauthorid0000-0002-8268-536X
dc.institutionauthorid0000-0003-1809-2655
dc.institutionauthorid0000-0003-3616-8051
dc.institutionauthorid0000-0002-6801-8499
dc.institutionauthorid0000-0001-6359-1600
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofPhotodiagnosis and Photodynamic Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcromegaly
dc.subjectGremlin-1
dc.subjectMicrovascular
dc.subjectOCTA
dc.subjectRetina
dc.titleChanges in retinal microvasculature and serum Gremlin-1 levels in acromegaly: A case-control study
dc.typeArticle

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