Therapeutic plasma exchange in critically ill children: A single center experience

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dc.authoridYazıcı Özkaya, Pınar/0000-0002-1209-2534
dc.authoridKoc, Gulizar/0000-0003-4961-9501
dc.authoridozdemir karadas, nihal/0000-0002-0019-7347
dc.contributor.authorOzkaya, Pinar Yazici
dc.contributor.authorKoc, Gulizar
dc.contributor.authorErsayoglu, Irem
dc.contributor.authorCebeci, Kuebra
dc.contributor.authorOzdemir, Hamiyet Hekimci
dc.contributor.authorKaradas, Nihal
dc.contributor.authorKarapinar, Deniz Yilmaz
dc.date.accessioned2024-08-31T07:47:48Z
dc.date.available2024-08-31T07:47:48Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: Therapeutic plasma exchange (TPE) is used in a wide spectrum of diseases in critically ill pediatric patients. We aim to review the indications, complications, safety, and outcomes of critically ill children who received TPE. Methods: All of the TPE procedures performed in a pediatric intensive care unit providing tertiary care during 19 years (January 2013-January 2023) were evaluated retrospectively. A total of 154 patients underwent 486 TPE sessions. Results: Median age was 6 years (2-12.5) and 35 children had a body weight of <10 kg (22.7%). Number of organ failure was 4 (2-6). Liver diseases were the most common indication for TPE (31.2%) followed by sepsis with multiorgan dysfunction syndrome (27.3%). Overall survival rate was 72.7%. The highest mortality was observed in hemophagocytic lymphohistiocytosis group. Non-survivors had significantly higher number of organ failure (p < 0.001), higher PRISM score (p < 0.001), and higher PELOD score on admission (p < 0.001). Adverse events were observed in 68 (13.9%) sessions. Hypotension (7.8%) and hypocalcemia (5.1%) were the most frequent adverse events. Conclusion: TPE is safe for critically ill pediatric patients with experienced staff. Survival rate may vary depending on the underlying disease. Survival decreases with the increase in the number of failed organs.en_US
dc.identifier.doi10.1111/1744-9987.14141
dc.identifier.issn1744-9979
dc.identifier.issn1744-9987
dc.identifier.pmid38747186en_US
dc.identifier.scopus2-s2.0-85193402777en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/1744-9987.14141
dc.identifier.urihttps://hdl.handle.net/11454/104550
dc.identifier.wosWOS:001222667100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofTherapeutic Apheresis and Dialysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectComplicationsen_US
dc.subjectCritically Ill Childrenen_US
dc.subjectIndicationsen_US
dc.subjectMultiorgan Dysfunction Syndromeen_US
dc.subjectTherapeutic Plasma Exchangeen_US
dc.titleTherapeutic plasma exchange in critically ill children: A single center experienceen_US
dc.typeArticleen_US

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