Animal Cell Lines as Expression Platforms in Viral Vaccine Production: A Post Covid-19 Perspective

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dc.contributor.authorDemirden, S. Furkan
dc.contributor.authorKimiz-Gebologlu, Ilgin
dc.contributor.authorOncel, Suphi S.
dc.date.accessioned2024-08-31T07:50:20Z
dc.date.available2024-08-31T07:50:20Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractVaccines are considered the most effective tools for preventing diseases. In this sense, with the Covid-19 pandemic, the effects of which continue all over the world, humanity has once again remembered the importance of the vaccine. Also, with the various epidemic outbreaks that occurred previously, the development processes of effective vaccines against these viral pathogens have accelerated. By these efforts, many different new vaccine platforms have been approved for commercial use and have been introduced to the commercial landscape. In addition, innovations have been made in the production processes carried out with conventionally produced vaccine types to create a rapid response to prevent potential epidemics or pandemics. In this situation, various cell lines are being positioned at the center of the production processes of these new generation viral vaccines as expression platforms. Therefore, since the main goal is to produce a fast, safe, and effective vaccine to prevent the disease, in addition to existing expression systems, different cell lines that have not been used in vaccine production until now have been included in commercial production for the first time. In this review, first current viral vaccine types in clinical use today are described. Then, the reason for using cell lines, which are the expression platforms used in the production of these viral vaccines, and the general production processes of cell culture-based viral vaccines are mentioned. Also, selection parameters for animal cell lines as expression platforms in vaccine production are explained by considering bioprocess efficiency and current regulations. Finally, all different cell lines used in cell culture-based viral vaccine production and their properties are summarized, with an emphasis on the current and future status of cell cultures in industrial viral vaccine production.en_US
dc.identifier.doi10.1021/acsomega.3c10484
dc.identifier.issn2470-1343
dc.identifier.pmid38645343en_US
dc.identifier.scopus2-s2.0-85189245535en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1021/acsomega.3c10484
dc.identifier.urihttps://hdl.handle.net/11454/105201
dc.identifier.wosWOS:001195912400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofACS Omegaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectSerum-Freeen_US
dc.subjectInfluenza Vaccineen_US
dc.subjectPer.C6(R) Cellsen_US
dc.subjectVero Cellsen_US
dc.subjectSuspension-Cultureen_US
dc.subjectMammalian-Cellsen_US
dc.subjectZycov-Den_US
dc.subjectVirusen_US
dc.subjectInsecten_US
dc.subjectSafetyen_US
dc.titleAnimal Cell Lines as Expression Platforms in Viral Vaccine Production: A Post Covid-19 Perspectiveen_US
dc.typeReview Articleen_US

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