Advances in Glioblastoma Multiforme Treatment: New Models for Nanoparticle Therapy

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dc.contributor.authorOzdemir-Kaynak, Elif
dc.contributor.authorQutub, Amina A.
dc.contributor.authorYesil-Celiktas, Ozlem
dc.date.accessioned2019-10-27T10:41:58Z
dc.date.available2019-10-27T10:41:58Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractThe most lethal form of brain cancer, glioblastoma multiforme, is characterized by rapid growth and invasion facilitated by cell migration and degradation of the extracellular matrix. Despite technological advances in surgery and radio-chemotherapy, glioblastoma remains largely resistant to treatment. New approaches to study glioblastoma and to design optimized therapies are greatly needed. One such approach harnesses computational modeling to support the design and delivery of glioblastoma treatment. In this paper, we critically summarize current glioblastoma therapy, with a focus on emerging nanomedicine and therapies that capitalize on cell-specific signaling in glioblastoma. We follow this summary by discussing computational modeling approaches focused on optimizing these emerging nanotherapeutics for brain cancer. We conclude by illustrating how mathematical analysis can be used to compare the delivery of a high potential anticancer molecule, delphinidin, in both free and nanoparticle loaded forms across the blood-brain barrier for glioblastoma.en_US
dc.identifier.doi10.3389/fphys.2018.00170en_US
dc.identifier.issn1664-042X
dc.identifier.pmid29615917en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3389/fphys.2018.00170
dc.identifier.urihttps://hdl.handle.net/11454/30570
dc.identifier.volume9en_US
dc.identifier.wosWOS:000427749500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers in Physiologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectglioblastomaen_US
dc.subjectdelphinidinen_US
dc.subjectnanoparticleen_US
dc.subjectcytoscapeen_US
dc.subjectblood-brain barrier modelingen_US
dc.titleAdvances in Glioblastoma Multiforme Treatment: New Models for Nanoparticle Therapyen_US
dc.typeReview Articleen_US

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