Oxytocin Improves Follicular Reserve in a Cisplatin-Induced Gonadotoxicity Model in Rats

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dc.contributor.authorErbas, Oytun
dc.contributor.authorAkman, Levent
dc.contributor.authorYavasoglu, Altug
dc.contributor.authorTerek, Mustafa Cosan
dc.contributor.authorAkman, Tulay
dc.contributor.authorTaskiran, Dilek
dc.date.accessioned2019-10-27T22:06:19Z
dc.date.available2019-10-27T22:06:19Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractCisplatin (CP), an antitumor agent, has been shown to cause ovarian injury and dysfunction in both animal and human studies. The present study was conducted to investigate the protective effect of oxytocin (OT) on CP-induced ovarian toxicity in rats. Twenty-one adult female rats were included in the study. Fourteen rats were administered intraperitoneally CP (2mg/kg/day) twice a week for 5 weeks. Control group (n = 7) did not receive any treatment. Following treatment, CP-received rats were randomly divided into two groups and treated with either saline (1 mL/kg/day, n = 7) or OT (160 mu g/kg/day, n = 7) for 5 weeks. Then, ovarian toxicity and effects of OT were evaluated by histomorphological and biochemical analysis. Our findings revealed a significant reduction in the number of follicles at each grade in saline-treated group. AMH level was significantly lower in saline group compared to control (P < 0.0005). OT treatment significantly attenuated CP toxicity in ovaries and increased AMH levels compared to saline group (P < 0.005). Also, administration of OT lessened lipid peroxidation and prevented glutathione depletion in CP-treated rats (P < 0.05). These results indicated that OT could lessen the CP-induced ovarian damage and improve follicular reserve by preventing oxidative damage.en_US
dc.identifier.doi10.1155/2014/703691en_US
dc.identifier.issn2314-6133
dc.identifier.issn2314-6141
dc.identifier.pmid24959584en_US
dc.identifier.urihttps://doi.org/10.1155/2014/703691
dc.identifier.urihttps://hdl.handle.net/11454/48772
dc.identifier.wosWOS:000336326900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofBiomed Research Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleOxytocin Improves Follicular Reserve in a Cisplatin-Induced Gonadotoxicity Model in Ratsen_US
dc.typeArticleen_US

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