Milnacipran attenuates hyperalgesia and potentiates antihyperalgesic effect of tramadol in rats with mononeuropathic pain

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dc.contributor.authorOnal, Aytul
dc.contributor.authorParlar, Ayse
dc.contributor.authorUlker, Sibel
dc.date.accessioned2019-10-27T19:58:57Z
dc.date.available2019-10-27T19:58:57Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractMilnacipran is a non-tricyclic antidepressant drug which selectively inhibits serotonin and noradrenaline re-uptake and is recommended in the treatment of various chronic pain syndromes. Many studies have shown that compounds known to block monoamine uptake potentiate the antinociceptive effects of opioids. This study investigates the effect of milnacipran alone or in combination with an opiodergic drug, i.e. tramadol, on hyperalgesia in a rat model of neuropathic pain. The contribution of serotonergic, noradrenergic and opioidergic systems in the potential antihyperalgesic effect of milnacipran has also been examined. Chronic constriction injury was induced in rats by loose ligation of the sciatic nerve and neuropathic pain was evaluated 14 days after surgery. Intraperitoneal acute injection of milnacipran 60 mg/kg produced an antihyperalgesic effect which was prevented by pretreating systemically with alpha-methyl-p-tyrosine, an inhibitor of noradrenaline synthesis; parachlorophenylalanine, an inhibitor of serotonin synthesis; and naloxone, an antagonist of opioidergic receptors. Co-administration of milnacipran 40 mg/kg with tramadol (20 and 40 mg/kg) potentiated the antihyperalgesic effect of tramadol. Milnacipran has an antihyperalgesic effect mediated by serotonergic, noradrenergic and opioidergic systems and the combined use of tramadol with milnacipran potentiates the effect of tramadol in the management of neuropathic pain. (C) 2007 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.pbb.2007.08.001en_US
dc.identifier.endpage178en_US
dc.identifier.issn0091-3057
dc.identifier.issue2en_US
dc.identifier.pmid17854875en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage171en_US
dc.identifier.urihttps://doi.org/10.1016/j.pbb.2007.08.001
dc.identifier.urihttps://hdl.handle.net/11454/41129
dc.identifier.volume88en_US
dc.identifier.wosWOS:000250641000006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPharmacology Biochemistry and Behavioren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmilnacipranen_US
dc.subjectantidepressive agentsen_US
dc.subjecthyperalgesiaen_US
dc.subjectpainen_US
dc.subjectsciatic neuropathyen_US
dc.titleMilnacipran attenuates hyperalgesia and potentiates antihyperalgesic effect of tramadol in rats with mononeuropathic painen_US
dc.typeArticleen_US

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