Arrhythmias in children undergoing orthotopic heart transplantation

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dc.authoridDoğan, Eser/0000-0002-0340-7741;
dc.contributor.authorDogan, Eser
dc.contributor.authorErgin, Firat
dc.contributor.authorBeyter, Mehmet B.
dc.contributor.authorKasikci, Guelcin K.
dc.contributor.authorOen, Seyma S.
dc.contributor.authorAy, Oguzhan
dc.contributor.authorLevent, Resit E.
dc.date.accessioned2024-08-31T07:47:12Z
dc.date.available2024-08-31T07:47:12Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroductionHeart transplantation (HT) is the only treatment option in children with heart failure secondary to cardiomyopathies and non-reparable congenital heart diseases.MethodsWe performed a retrospective clinical data review of all consecutive pediatric patients (aged 2-18 years) who underwent orthotopic HT for advanced heart failure at our institution between January 2007 and January 2023. Clinical, procedural, and follow-up data were collected and comprehensively analyzed.ResultsWe identified 27 children (66.7% males) with a median age of 15 years (IQR: 7-16) and a median weight of 45 kg (IQR: 22-66) at the time of the intervention. 24 patients (88.8%) were diagnosed with dilated cardiomyopathy, 2 (7.4%) with restrictive cardiomyopathy, and 1 (3.7%) with hypertrophic cardiomyopathy. On a median follow-up of 35.07 months (IQR: 13.13-111.87), arrhythmias were detected in 9 (33%) patients. Three patients developed symptomatic sinus node dysfunction at 18, 25, and 38 days and received permanent pacemakers. One patient developed a complete AV block during acute rejection at 76 months and received a temporary pacemaker. Two patients developed chronic sinus tachycardia at 4 and 16 months and were treated with Beta-blockers after eliminating all causes of sinus tachycardia. One patient developed a complete right bundle branch block at 12 months. One patient developed ventricular extrasystole at 10 months and was found to have grade 2 rejection. An Atrial extrasystole was detected in one patient at 96 months. We did not identify significant risk factors for arrhythmias post-HT.DiscussionAfter pediatric HT, early-onset rhythm disturbances, often attributed to surgery-related issues such as sinus node dysfunction, may necessitate invasive treatments like permanent pacemaker therapy. Close monitoring post-transplantation is crucial, and routine follow-up with Holter ECG is necessary to identify potential rhythm disorders even in the absence of symptoms. Rhythm disturbances that develop during follow-up can serve as early indicators of graft rejection and should be carefully evaluated.en_US
dc.description.sponsorshipThe author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.en_US
dc.description.sponsorshipNo Statement Availableen_US
dc.identifier.doi10.3389/fcvm.2023.1323958
dc.identifier.issn2297-055X
dc.identifier.pmid38274311en_US
dc.identifier.scopus2-s2.0-85183056200en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3389/fcvm.2023.1323958
dc.identifier.urihttps://hdl.handle.net/11454/104332
dc.identifier.volume10en_US
dc.identifier.wosWOS:001148290100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers In Cardiovascular Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectArrhythmiaen_US
dc.subjectPediatricen_US
dc.subjectTransplantation (Heart)en_US
dc.subjectEcgen_US
dc.subjectHolter Ecgen_US
dc.titleArrhythmias in children undergoing orthotopic heart transplantationen_US
dc.typeArticleen_US

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