Synthesis of some 2(3H)-benzoxazolone derivatives and their in-vitro effects on human leukocyte myeloperoxidase activity

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dc.contributor.authorSoyer, Z
dc.contributor.authorBas, M
dc.contributor.authorPabuccuoglu, A
dc.contributor.authorPabuccuoglu, V
dc.date.accessioned2019-10-27T19:23:18Z
dc.date.available2019-10-27T19:23:18Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractMyeloperoxidase (MPO), a heme protein expressed by polymorphonuclear leukocytes, generates potent oxidants which are proposed to contribute to tissue damage during inflammation and certain pathogenesis such as neurodegenerative disorders. In this study, twenty omega-[2-oxo-3H-benzoxazol-3-yl]-N-phenylacetamide and propionamide derivatives having substituents of different lipophilic and electronic nature on the N-phenyl ring were synthesized to evaluate the inhibitory effects on in vitro leukocyte MPO chlorinating activity. The most active compounds in the series were the derivatives bearing 2-methyl and 4-nitro substituent on the N-phenyl ring.en_US
dc.identifier.doi10.1002/ardp.200500106en_US
dc.identifier.endpage410en_US
dc.identifier.issn0365-6233
dc.identifier.issue9en_US
dc.identifier.pmid16143956en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage405en_US
dc.identifier.urihttps://doi.org/10.1002/ardp.200500106
dc.identifier.urihttps://hdl.handle.net/11454/39174
dc.identifier.volume338en_US
dc.identifier.wosWOS:000232313800002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofArchiv Der Pharmazieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2(3H)-benzoxazoloneen_US
dc.subjectanilideen_US
dc.subjectmyeloperoxidaseen_US
dc.titleSynthesis of some 2(3H)-benzoxazolone derivatives and their in-vitro effects on human leukocyte myeloperoxidase activityen_US
dc.typeArticleen_US

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