Assessment of toll-like receptor-4 gene polymorphism on pyelonephritis and renal scar

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dc.contributor.authorAkil I.
dc.contributor.authorÖzkınay F.
dc.contributor.authorOnay H.
dc.contributor.authorCanda E.
dc.contributor.authorGumuser G.
dc.contributor.authorKavukcu S.
dc.date.accessioned2019-10-26T21:45:54Z
dc.date.available2019-10-26T21:45:54Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the effect of the TLR-4 gene TLR4 c.896A<G polymorphism on the development and clinical severity of urinary tract infections (UTI) and renal scar formations in children. The patients with first diagnosis of UTI (n=112) and healthy controls (n=93) were enrolled in the study. The TLR4 c.896A<G polymorphism was analysed in groups. The mean age of the patients in the study group was 8.1±3.5years and 9.2±2.7years for those in the control group. The TLR4 c.896A<G polymorphism was detected in 12.5% in the UTI group and in 15.1% of the control group. Forty patients showed pyelonephritis (PN) with scar tissue, 37 patients had PN without scars, and 35 patients had lower UTI. The TLR4 c.896A<G polymorphism was found in 22.5% of patients with scar-positive PN, and it was also present in 10.8% of patients with scar-negative PN and 2.9% of patients with lower UTI. We found higher TLR4 c.896A<G polymorphism and allelic frequency in patients with upper UTI compared to patients with lower UTI (P=0.041 and P=0.039, respectively). No significant difference was observed between patients and the control group for TLR-4 c.896A3. The TLR4 c.896A<G polymorphism and alleles were higher in patients with upper UTI than in patients with lower UTI. The TLR4 c.896A<G polymorphism frequency was nearly twice that in the scar-positive PN patients when compared to the scar-negative patients. Larger-scale studies involving larger numbers of patients should be performed. © 2012 Blackwell Publishing Ltd.en_US
dc.identifier.doi10.1111/j.1744-313X.2012.01090.xen_US
dc.identifier.endpage307en_US
dc.identifier.issn1744-3121
dc.identifier.issue4en_US
dc.identifier.pmid22308961en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage303en_US
dc.identifier.urihttps://doi.org/10.1111/j.1744-313X.2012.01090.x
dc.identifier.urihttps://hdl.handle.net/11454/18531
dc.identifier.volume39en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofInternational Journal of Immunogeneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleAssessment of toll-like receptor-4 gene polymorphism on pyelonephritis and renal scaren_US
dc.typeArticleen_US

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