Small Frontal Gray Matter Volume in First-Episode Depression Patients

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dc.contributor.authorBilgj, Mustafa Melih
dc.contributor.authorOzalay, Ozgun
dc.contributor.authorEker, Mehmet Cagdas
dc.contributor.authorKitis, Omer
dc.contributor.authorOzan, Erol
dc.contributor.authorEker, Ozlem
dc.contributor.authorSimsek, Fatma
dc.contributor.authorHaznedaroglu, Damla Isman
dc.contributor.authorGonul, Ali Saffet
dc.date.accessioned2019-10-27T21:15:29Z
dc.date.available2019-10-27T21:15:29Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Brain imaging studies have shown that depressed individuals suffer from inadequate frontal lobefunctions vis a vis smaller frontal lobes. The effects of depression's recurrent nature and long-term antidepressant treatment are not definitely known. This study aimed to examine frontal lobe volume at the onset of clinical depression by including first-episode drug-naive depressed patients. Method: The study included 23 first-episode drug-free major depression patients diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) and 28 healthy age- and sex-matched controls. Cranial magnetic resonance (MR) images were obtained in both groups using a 1.5 Tesla device. Gray and white matter volumes in the frontal lobes were measured using the Medical Image Processing Analysis and Visualization (MIPAV) computer program. Results: Frontal gray matter volume in the patients was lower than that in the control group. White matter and total intracranial volume did not differ between the 2 groups. Small gray matter volume was not correlated with the duration or severity of illness. Conclusion: The results of this study indicate that frontal lobe gray matter volume is low in first-episode depressed patients and is independent of both illness severity and duration. This result suggests that the observed changes in the frontal lobe could have occurred before the clinical symptoms of depression were observed.en_US
dc.identifier.endpage194en_US
dc.identifier.issn1300-2163
dc.identifier.issue3en_US
dc.identifier.pmid20818506en_US
dc.identifier.startpage185en_US
dc.identifier.urihttps://hdl.handle.net/11454/43544
dc.identifier.volume21en_US
dc.identifier.wosWOS:000281709900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherTurkiye Sinir Ve Ruh Sagligi Dernegien_US
dc.relation.ispartofTurk Psikiyatri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDepressionen_US
dc.subjectcerebral cortexen_US
dc.subjectfrontal lobeen_US
dc.subjectMRIen_US
dc.titleSmall Frontal Gray Matter Volume in First-Episode Depression Patientsen_US
dc.typeArticleen_US

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