Successful treatment of hepatic and mesh Aspergillosis in a neonate with giant omphalocele

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dc.authoridGüner Özenen, Gizem/0000-0002-9725-7501
dc.authorscopusid57414445400
dc.authorscopusid38061964200
dc.authorscopusid57221502271
dc.authorscopusid57222327020
dc.authorscopusid57414605000
dc.authorscopusid57414918300
dc.authorscopusid7004343654
dc.authorwosidGüner Özenen, Gizem/ABG-2316-2021
dc.contributor.authorArslan, S. Yildirim
dc.contributor.authorBal, Z. Sahbudak
dc.contributor.authorOzenen, G. Guner
dc.contributor.authorBilen, N. M.
dc.contributor.authorNaghiyev, J.
dc.contributor.authorSakul, G.
dc.contributor.authorOzkinay, F.
dc.date.accessioned2023-01-12T19:55:55Z
dc.date.available2023-01-12T19:55:55Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractAspergillosis is a rare and life-threatening fungal infection in immunocompetent children, particularly in infants. We present a case of invasive Aspergillosis (IA) that developed hepatic and mesh infection due to Aspergillus flavus following the rupture of a giant omphalocele. A male baby was born at 37 weeks of gestation with a giant omphalocele. No other congenital abnormalities were found. In the pediatric surgery operation room, the amniotic membrane seemed to be ruptured in some parts, which had been repaired within a few hours of birth. No further intervention to reduce the volume of visceral organs could be performed due to the tiny abdominal cavity. Postoperatively piperacillin-tazobactam and fluconazole were empirically initiated. Abdominal defects had been covered with polypropylene polylactic acid synthetic Mesh on postnatal day 11 to protect the organs and prevent abdominal infections. Fungal hepatic lesions were observed during surgery, and black necrotic lesions were also observed on the mesh on day 12. On the 16th postnatal day, Aspergillus flavus grew in the wound, graft, hepatic biopsy cultures. Serum galactomannan (GM) assay test was positive (GM:2.9), and voriconazole was initiated. All necrotic lesions resolved with liposomal amphotericin B (L-AmB) and voriconazole treatment, and antifungal therapy was discontinued after 134 days. Eye examination for the retinopathy didn't show any abnormalities. The patient was discharged with full recovery on day 155. In conclusion, IA is a rare and life-threatening infection in the neonatal period. To the best of our knowledge, this is the first case of hepatic and mesh infection caused by Aspergillus flavus that was successfully treated with voriconazole and L-AmB. (C) 2022 SFMM. Published by Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.mycmed.2022.101245
dc.identifier.issn1156-5233
dc.identifier.issn1773-0449
dc.identifier.issue2en_US
dc.identifier.pmid35063761en_US
dc.identifier.scopus2-s2.0-85122929233en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.mycmed.2022.101245
dc.identifier.urihttps://hdl.handle.net/11454/76772
dc.identifier.volume32en_US
dc.identifier.wosWOS:000800535500004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMasson Editeuren_US
dc.relation.ispartofJournal De Mycologie Medicaleen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAspergillus flavusen_US
dc.subjectNeonateen_US
dc.subjectGiant omphaloceleen_US
dc.subjectVoriconazoleen_US
dc.subjectLiposomal amphotericin ben_US
dc.subjectCutaneous Aspergillosisen_US
dc.subjectPremature-Infanten_US
dc.subjectAmphotericin-Ben_US
dc.subjectGastroschisisen_US
dc.subjectVoriconazoleen_US
dc.titleSuccessful treatment of hepatic and mesh Aspergillosis in a neonate with giant omphaloceleen_US
dc.typeArticleen_US

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