Demonstration of Epstein-Barr Virus by In Situ Hybridization in Papillary Thyroid Carcinomas Developing on Background of Hashimoto's Thyroiditis

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dc.contributor.authorKaraarslan, Serap
dc.contributor.authorKasap, Esin
dc.contributor.authorIpek, Fatma Nur
dc.contributor.authorAkyildiz, Mahir
dc.date.accessioned2024-08-31T07:48:19Z
dc.date.available2024-08-31T07:48:19Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractAim This study aimed to demonstrate the role of Epstein-Barr Virus (EBV) in papillary thyroid carcinomas (PTC) developing on the background of Hashimoto's thyroiditis (HT). Methods The presence of EBV in tumoral tissue, lymphocytes, and peritumoral normal thyroid tissue was investigated using the in situ hybridization method in paraffin blocks. The subtypes of PTC, tumor diameter, TNM stage, multifocality, invasion of thyroid capsule, perineural invasion, and muscular tissue invasion were identified and compared according to EBV involvement. Results Eighty-one patients with HT diagnosis, with 93.8% (n=76) female and 6.2% (n=5) male, were included in the study. Papillary microcarcinoma was the pathological diagnosis in 24.2% (n=15) of the cases. EBV was identified in 58.06% (n=36) of the tumor cells nuclei, 58.06% (n=36) in the tumor cell cytoplasm, 16.12% (n=10) in tumor infiltrative lymphocytes, and 53.2% (n=33) in normal parenchymal follicle epithelial cells (NPFEC). In the T2 stage, the rate of EBV nuclear positivity in patients was significantly higher (p=0.034). The classic variant of papillary carcinoma was accompanied by a significantly higher rate of EBV-negative NPFEC (67.6%, p=0.049). In multifocal tumors, EBV positivity was found to be significantly higher in lymphocytes in the surrounding tissues (58.3%, p=0.034). Conclusion A significant increase in EBV positivity in the surrounding tissue lymphocytes was observed in multifocal PTC developing on a background of HT. This suggests a possible association between HT and EBV.en_US
dc.identifier.doi10.1055/a-2322-7355
dc.identifier.endpage475en_US
dc.identifier.issn0947-7349
dc.identifier.issn1439-3646
dc.identifier.issue8en_US
dc.identifier.pmid38718832en_US
dc.identifier.scopus2-s2.0-85193236573en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage469en_US
dc.identifier.urihttps://doi.org/10.1055/a-2322-7355
dc.identifier.urihttps://hdl.handle.net/11454/104723
dc.identifier.volume132en_US
dc.identifier.wosWOS:001262139400002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofExperimental and Clinical Endocrinology & Diabetesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectEpstein-Barr Virusen_US
dc.subjectThyroid Papillary Carcinomaen_US
dc.subjectHashimoto Thyroiditisen_US
dc.subjectMicrocarcinomaen_US
dc.subjectMultifocalityen_US
dc.titleDemonstration of Epstein-Barr Virus by In Situ Hybridization in Papillary Thyroid Carcinomas Developing on Background of Hashimoto's Thyroiditisen_US
dc.typeArticleen_US

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