Hypericum triquetrifolium Turra. extract exhibits antiinflammatory activity in the rat
Küçük Resim Yok
Tarih
2002
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Ireland Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of the present study was to explore the probable antiinflammatory effect of Hypericum triquetrifolium Turra. in a rat model of carrageenan induced inflammation. Male Wistar rats were treated intraperitoneally with 0.4% dimethlsulphoxide (DMSO) (as control group) and H. triquetrifolium extract (25, 50, 60 mg/kg), 30 min before 0.1 ml 1% carrageenan injection. Paw volume was measured before and 1, 2, 3, 4, 5 and 6 h after the injection of carrageenan. The results are expressed as the mean+/-s.e. mean and the statistical significance of differences between groups was analyzed by One Way Analysis of Variance (ANOVA). The intraplantar injection of carrageenan caused a time-dependent paw edema in the rat although saline injection caused no swelling. Intraperitoneal administration of H. triquetrifolium extract (25, 50, 60 mg/kg) inhibited paw swelling dose-dependently at 2. 3. 4. 5 and 6 h after carrageenan injection (P < 0.05). We can conclude that H. triquetrifolium extract may exert an antinflammatory effect in rats. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Hypericum triquetrifolium, antiinflammatory effect, rat, plant extract
Kaynak
Journal of Ethnopharmacology
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
80
Sayı
02.Mar
