Acute hypoxia exposure following prenatal stress impairs hippocampus and novelty-seeking behavior in adolescent rats

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dc.authoridSozmen, Eser Y./0000-0002-6383-6724
dc.authoridGARIP, GURUR/0000-0002-2999-477X
dc.authoridCELIK, Kubra/0000-0002-0161-6179
dc.authorscopusid57377969200
dc.authorscopusid57377811000
dc.authorscopusid57325725800
dc.authorscopusid57517774400
dc.authorscopusid7004558658
dc.authorscopusid10043156900
dc.authorwosidSozmen, Eser Y./ABI-5243-2020
dc.contributor.authorCelik, Kubra
dc.contributor.authorBilim, Petek
dc.contributor.authorGarip, Gurur
dc.contributor.authorDurmaz, Burak
dc.contributor.authorSozmen, Eser Yildirim
dc.contributor.authorBaka, Meral
dc.date.accessioned2023-01-12T19:49:50Z
dc.date.available2023-01-12T19:49:50Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractObjectives The present study aimed to investigate the effects of acute hypoxia exposure following prenatal stress on the novelty-seeking behavior and hippocampus of adolescent rats. Methods The offspring were divided into prenatal stress (PS) and non-stress (NS) groups. Both groups were exposed to hypoxia on postnatal day 10 (P10) while control groups were undisturbed. Novel object recognition task was performed in each group. Next, brains were collected to examine hippocampus via immunohistochemical and biochemical studies on postnatal day 35 (P35). Results PS decreased novelty discrimination and synaptophysin (SYN) expressions in both CA1 and CA3 of the hypoxia group prominently (p < 0.05). Nestin-expressing cells were reduced while vascular endothelial growth factor (VEGF) expression was enhanced in the subgranular zone (SGZ) of PS-hypoxia group (p < 0.05). VEGF enhancement triggered angiogenesis in the CA1 and CA3 significantly (p < 0.05). PS also increased thiobarbituric acid reactive substances (TBARS) levels in the hypoxia group as a result of oxidative stress (p < 0.05). Conclusion These findings demonstrated that PS exacerbates neurodevelopmental deficits in the hippocampus of acute hypoxia-induced offspring in adolescence.en_US
dc.description.sponsorshipEge University [18-SBE-004/2018]en_US
dc.description.sponsorshipEge University, Grant/Award Number: 18-SBE-004/2018en_US
dc.identifier.doi10.1002/jdn.10162
dc.identifier.endpage95en_US
dc.identifier.issn0736-5748
dc.identifier.issn1873-474X
dc.identifier.issue1en_US
dc.identifier.pmid34850973en_US
dc.identifier.scopus2-s2.0-85121418079en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage85en_US
dc.identifier.urihttps://doi.org/10.1002/jdn.10162
dc.identifier.urihttps://hdl.handle.net/11454/75930
dc.identifier.volume82en_US
dc.identifier.wosWOS:000731829400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Developmental Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthippocampusen_US
dc.subjecthypoxiaen_US
dc.subjectnovelty-seekingen_US
dc.subjectprenatal stressen_US
dc.subjectOxidative Stressen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectImmature Raten_US
dc.subjectIncreasesen_US
dc.subjectMemoryen_US
dc.subjectExpressionen_US
dc.subjectPregnancyen_US
dc.subjectSeizuresen_US
dc.subjectDensityen_US
dc.subjectNeuronsen_US
dc.titleAcute hypoxia exposure following prenatal stress impairs hippocampus and novelty-seeking behavior in adolescent ratsen_US
dc.typeArticleen_US

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