Impaired quality of life, disability and mental health in Takayasu's arteritis

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dc.contributor.authorYilmaz, Neslihan
dc.contributor.authorCan, Meryem
dc.contributor.authorOner, Fatma Alibaz
dc.contributor.authorKalfa, Melike
dc.contributor.authorEmmungil, Hakan
dc.contributor.authorKaradag, Omer
dc.contributor.authorYildiz, Fatih
dc.contributor.authorKimyon, Gezmis
dc.contributor.authorYilmazer, Baris
dc.contributor.authorGerdan, Vedat
dc.contributor.authorBilge, Sule Yasar
dc.contributor.authorIlhan, Birkan
dc.contributor.authorCobankara, Veli
dc.contributor.authorKasifoglu, Timucin
dc.contributor.authorCefle, Ayse
dc.contributor.authorKisacik, Bunyamin
dc.contributor.authorOnat, Ahmet Mesut
dc.contributor.authorAkar, Servet
dc.contributor.authorOnen, Fatos
dc.contributor.authorErken, Eren
dc.contributor.authorKiraz, Sedat
dc.contributor.authorAksu, Kenan
dc.contributor.authorKeser, Gokhan
dc.contributor.authorMumcu, Gonca
dc.contributor.authorDireskeneli, Haner
dc.date.accessioned2019-10-27T22:07:54Z
dc.date.available2019-10-27T22:07:54Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective. Patient-reported outcomes (PROs) are increasingly accepted to be among the major tools for outcome assessment in rheumatic disorders. In this study we aimed to assess quality of life (QoL), disability, anxiety and depression in patients with Takayasu's arteritis (TAK). Methods. Patients followed with the diagnosis of TAK (n = 165) and healthy controls (HCs) (n = 109) were enrolled to the study. The 36-item Short Form Health Survey (SF-36) and hospital anxiety and depression scales (HADS) were used to assess QoL and mental status together with HAQ for disability. Results. In SF-36 subscale assessment, all items were observed to be statistically lower in TAK patients; similarly HAQ scores were also higher (P < 0.001) in this group. In mental assessment, anxiety was found to be more common in TAK patients [90 (54.5%) vs 38 (34.9%), P = 0.001]. Depression also tended to be higher in TAK patients [70 (66.7%) vs 35 (33.3%)], without reaching significance (P = 0.086). Most of the SF-36 subgroup parameters were lower in TAK patients with active disease. Patients having anxiety and depression or with high HAQ scores reported worse SF-36 scores. In multivariate analysis, HADS-A, HADS-D and HAQ were associated with most SF-36 subscales. Conclusion. PROs demonstrate that not only general health but also physical and social functioning with physical role limitations and mental health parameters were impaired in TAK. Our results, especially in active disease, suggest that PROs such as SF-36 can be core domains of disease assessment in TAK, similar to ANCA-associated vasculitides.en_US
dc.identifier.doi10.1093/rheumatology/ket238en_US
dc.identifier.endpage1904en_US
dc.identifier.issn1462-0324
dc.identifier.issn1462-0332
dc.identifier.issue10en_US
dc.identifier.pmid23873821en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1898en_US
dc.identifier.urihttps://doi.org/10.1093/rheumatology/ket238
dc.identifier.urihttps://hdl.handle.net/11454/49095
dc.identifier.volume52en_US
dc.identifier.wosWOS:000325997900026en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofRheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTakayasu's arteritisen_US
dc.subjectquality of lifeen_US
dc.subjectfunctionen_US
dc.subjectmental statusen_US
dc.titleImpaired quality of life, disability and mental health in Takayasu's arteritisen_US
dc.typeArticleen_US

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