Prognostic significance of tumor budding in muscle invasive urothelial carcinomas of the bladder

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dc.contributor.authorKucuk, Ulku
dc.contributor.authorEkmekci, Sumeyye
dc.contributor.authorCakir, Ebru
dc.contributor.authorEkin, Zubeyde
dc.contributor.authorErgani, Batuhan
dc.contributor.authorEkin, Gokhan Rahmi
dc.date.accessioned2019-10-27T09:43:13Z
dc.date.available2019-10-27T09:43:13Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to evaluate the prognostic significance of tumor budding in muscle invasive urothelial carcinoma of bladder (MIBC). Material and methods: A total of 60 patients who underwent radical cystectomy and cystoprostatectomy for MIBC were included in the study. The correlations between tumor budding, and tumor necrosis, lymphovascular invasion (LVI), perineural invasion (PNI) and histopathological data with distant metastasis were evaluated. The correlation between progression free (PFS) and overall survival (OS) rates and the presence, and grade of tumor budding was investigated. Results: A statistically significant correlation was not seen between tumor budding, necrosis, LVI, and PNI. There was a strong correlation between distant organ metastasis, and presence of tumor necrosis. There was no statistically significant correlation between PFS, OS and tumor budding. A statistically significant relationship was observed between OS and tumor stage, lymph node metastasis, and distant organ metastasis. Conclusion: In our study, statistically significant effect of tumor budding on survival rates in MIBCs was not observed. Also, no significant correlation was observed between tumor budding and tumor necrosis, LVI, and PNI.en_US
dc.identifier.doi10.5152/tud.2018.58269en_US
dc.identifier.endpage278en_US
dc.identifier.issn2149-3235
dc.identifier.issn2149-3057
dc.identifier.issue4en_US
dc.identifier.pmid30183610en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage273en_US
dc.identifier.urihttps://doi.org/10.5152/tud.2018.58269
dc.identifier.urihttps://hdl.handle.net/11454/28852
dc.identifier.volume45en_US
dc.identifier.wosWOS:000474443200007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBladderen_US
dc.subjecttumor buddingen_US
dc.subjecturothelial carcinomaen_US
dc.titlePrognostic significance of tumor budding in muscle invasive urothelial carcinomas of the bladderen_US
dc.typeArticleen_US

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