Gingival Crevicular Fluid and Plasma Acute-Phase Cytokine Levels in Different Periodontal Diseases

Basit Öğe Kaydı
dc.contributor.authorBecerik, Sema
dc.contributor.authorOzturk, Veil Ozgen
dc.contributor.authorAtmaca, Harika
dc.contributor.authorAtilla, Gul
dc.contributor.authorEmingil, Gulnur
dc.date.accessioned2019-10-27T21:41:05Z
dc.date.available2019-10-27T21:41:05Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: The aim of the present study is to investigate gingival crevicular fluid (GCF) and plasma acute-phase cytokines, interleukin-I beta (IL-1 beta), interleukin-6 (IL-6), interleukin-11 (IL-11), oncostatin M (OSM), and leukemia inhibitory factor (LIF) levels in patients with different periodontal diseases. Methods: Eighty individuals were included in this study; 20 with chronic periodontitis (CP), 20 with generalized aggressive periodontitis (GAgP), 20 with gingivitis, and 20 classified as healthy (H). Probing depth, clinical attachment level, plaque index, and papilla bleeding index were recorded. Plasma and GCF IL-1 beta, IL-6, IL-11, OSM, and LIF levels were analyzed by enzyme-linked immunosorbent assay. Results: CP and GAgP groups had significantly higher GCF IL-1 beta, IL-6, and IL-11 levels when compared with the H group (P <0.05). Conversely, GCF LIF levels of the CP and GAgP groups were lower than those of the H group (P<0.05). GCF OSM levels did not differ significantly among study groups. Plasma levels of all the cytokines studied were not significantly different among the study groups. Conclusions: Based on the present data, elevated IL-1 beta, IL-6, and IL-11 GCF levels, but not plasma levels, are suggested as reliable inflammatory biomarkers in periodontal diseases. Decreased LIF levels in diseased groups might reflect the possible beneficial effects of LIF in the modulation of inflammatory response in gingiva. J Periodontol 2012;83: 1304-1313.en_US
dc.description.sponsorshipEge UniversityEge University [09DIS-22]en_US
dc.description.sponsorshipThis work was supported by Research Fund of Ege University Project 09DIS-22. The authors thank Assoc. Prof. Mehmet Orman, Department of Biostatistics and Medical Informatics, School of Medicine, Ege University, for his help in statistical analysis. The authors report no conflicts of interest related to this study.en_US
dc.identifier.doi10.1902/jop.2012.110616en_US
dc.identifier.endpage1313en_US
dc.identifier.issn0022-3492
dc.identifier.issn1943-3670
dc.identifier.issue10en_US
dc.identifier.pmid22248224en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1304en_US
dc.identifier.urihttps://doi.org/10.1902/jop.2012.110616
dc.identifier.urihttps://hdl.handle.net/11454/46538
dc.identifier.volume83en_US
dc.identifier.wosWOS:000309793800013en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Periodontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInterleukin-1 betaen_US
dc.subjectinterleukin-6en_US
dc.subjectinterleukin-11en_US
dc.subjectleukemia inhibitory factoren_US
dc.subjectoncostatin Men_US
dc.subjectperiodontitisen_US
dc.titleGingival Crevicular Fluid and Plasma Acute-Phase Cytokine Levels in Different Periodontal Diseasesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu