Anticancer effect evaluation of nitron complexes

Basit Öğe Kaydı
dc.contributor.authorOzdemir, Vedat Tolga
dc.contributor.authorKavukcu, Serdar Batikan
dc.contributor.authorCaglar, Ayse Dila
dc.contributor.authorNalbantsoy, Ayse
dc.contributor.authorTurkmen, Hayati
dc.date.accessioned2024-08-31T07:49:49Z
dc.date.available2024-08-31T07:49:49Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractThis investigation scrutinizes the cytotoxic properties inherent in nitron metal complexes, a commercially available 1,2,4-triazole derivative. The study assesses the anticancer potential of ruthenium(II) (1), rhodium(III) (2), iridium(I/III) (3 and 5), palladium(II) (4), and platinum(II) (6) complexes of nitron by subjecting them to examination as agents against cancer cell lines, namely HeLa, MDA-MB-231, PC3, and non-cancerous CCD-34Lu cells. Results derived from the MTT assay substantiate that each nitron complex manifests cytotoxic activity against a spectrum of cancer cells. Notably, the ruthenium (Ru) and rhodium (Rh) complexes exhibit pronounced cytotoxic effects on cancer cells, suggesting their potential as impactful chemotherapeutic agents. Flow cytometry studies further reveal a predilection of these complexes towards inducing early apoptosis in the target cells. The investigation extends to exploring the stability and aquation dynamics of complex (1), in addition to elucidating the binding model between complex (1) and DNA.en_US
dc.description.sponsorshipEge University Scientific Research Projects [23566]en_US
dc.description.sponsorshipFinancial Support from Ege University Scientific Research Projects (Project No: 23566) is gratefully acknowledged. They would like to thank Ege University Planning and Monitoring Coordination of Organizational Development and Directorate of Library and Documentation for providing in editing and proofreading service of this study.en_US
dc.identifier.doi10.1016/j.inoche.2023.111963
dc.identifier.issn1387-7003
dc.identifier.issn1879-0259
dc.identifier.scopus2-s2.0-85181692250en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.inoche.2023.111963
dc.identifier.urihttps://hdl.handle.net/11454/105011
dc.identifier.volume160en_US
dc.identifier.wosWOS:001154189300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInorganic Chemistry Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectNitronen_US
dc.subjectN -Heterocyclic Carbene (Nhc)en_US
dc.subjectAnticancer Agenten_US
dc.subjectCytotoxic Activityen_US
dc.subjectMetal Based Anticancer Drugen_US
dc.subjectFs-Dna Interactionen_US
dc.titleAnticancer effect evaluation of nitron complexesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu