Anticancer effect evaluation of nitron complexes

This investigation scrutinizes the cytotoxic properties inherent in nitron metal complexes, a commercially available 1,2,4-triazole derivative. The study assesses the anticancer potential of ruthenium(II) (1), rhodium(III) (2), iridium(I/III) (3 and 5), palladium(II) (4), and platinum(II) (6) complexes of nitron by subjecting them to examination as agents against cancer cell lines, namely HeLa, MDA-MB-231, PC3, and non-cancerous CCD-34Lu cells. Results derived from the MTT assay substantiate that each nitron complex manifests cytotoxic activity against a spectrum of cancer cells. Notably, the ruthenium (Ru) and rhodium (Rh) complexes exhibit pronounced cytotoxic effects on cancer cells, suggesting their potential as impactful chemotherapeutic agents. Flow cytometry studies further reveal a predilection of these complexes towards inducing early apoptosis in the target cells. The investigation extends to exploring the stability and aquation dynamics of complex (1), in addition to elucidating the binding model between complex (1) and DNA.