G protein ß3 subunit gene polymorphism in Turkish hypertensives

Basit Öğe Kaydı
dc.contributor.authorAlioglu E.
dc.contributor.authorErcan E.
dc.contributor.authorTengiz I.
dc.contributor.authorYildiz A.
dc.contributor.authorSaygi U.ö.T.S.
dc.contributor.authorÇam F.S.
dc.contributor.authorBerdeli A.
dc.date.accessioned2019-10-26T23:56:30Z
dc.date.available2019-10-26T23:56:30Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: G protein is one of the most important regulators of intracellular signaling pathways. C825T polymorphism of G protein ß3 subunit is associated with increased intracellular signal transduction. The 825T allele has been found associated with a variety of cardiovascular risk factors, including hypertension. The aim of the present study was to investigate the association between the C825T polymorphism of the G protein ß3 subunit and essential hypertension in Turkish population. Methods: This cross-sectional, case-controlled study included 209 patients with essential hypertension (Patient group) and 82 subjects with normal blood pressure (Control group). The G protein ß3 subunit C825T gene polymorphism was determined by polymerase chain reaction. Hypertension was defined according to JNC VII criteria. Statistical analysis was performed using Chi square and unpaired t tests. Logistic regression analysis was used to study association between hypertension and genotypes. Results: We found that the frequencies of the G protein ß3 subunit C825T polymorphism in hypertensive and control groups were 17.7%, 59.3%, 23.0% and 32.9%, 48.8%, 18.3%, (CC, CT, TT) respectively (?2=7.963, p=0.019). In the multivariate logistic regression analysis CT genotype had 2.2 (OR=2.262, 95% CI 1.228-4.167, p=0.009), and TT genotype had 2.3 times (OR=2.335, 95% CI 1.089-5.008, p=0.029) greater risk of hypertension compared to CC genotype. Conclusion: It seems that the G protein ß3 subunit C825T gene polymorphism is associated with systolic a diastolic blood pressure. Furthermore, the study indicates that the G protein ß3 subunit may be a susceptible gene to essential hypertension.en_US
dc.identifier.endpage335en_US
dc.identifier.issn1302-8723
dc.identifier.issue5en_US
dc.identifier.pmid18849222en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage331en_US
dc.identifier.urihttps://hdl.handle.net/11454/20818
dc.identifier.volume8en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofAnadolu Kardiyoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectG proteinen_US
dc.subjectGeneen_US
dc.subjectGeneticsen_US
dc.subjectHypertensionen_US
dc.subjectLogistic regression analysisen_US
dc.subjectPolymorphismen_US
dc.subjectPredictive modelsen_US
dc.titleG protein ß3 subunit gene polymorphism in Turkish hypertensivesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu