Formulation and Evaluation of Organogels Containing Hyaluronan Microparticles for Topical Delivery of Caffeine

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dc.contributor.authorSimsolo, Erol Eli
dc.contributor.authorEroglu, Ipek
dc.contributor.authorTanriverdi, Sakine Tuncay
dc.contributor.authorOzer, Ozgen
dc.date.accessioned2019-10-27T10:07:22Z
dc.date.available2019-10-27T10:07:22Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractCellulite is a dermal disorder including the extracellular matrix, the lymphatic and microcirculatory systems and the adipose tissue. Caffeine is used as the active moiety depending its preventive effect on localization of fat in the cellular structure. Hyaluronic acid (hyaluronan-HA) is a natural constituent of skin that generates formation and poliferation of new cells having a remarkable moisturizing ability. The aim of this study is to formulate HA microparticles loaded with caffeine via spray-drying method. Resulting microparticle formulations (33.97 +/- 0.3 mu m, span < 2, 88.56 +/- 0.42% encapsulation efficiency) were distributed in lecithin organogels to maintain the proper viscosity for topical application. Following the characterization and cell culture studies, in vitro drug release and ex vivo permeation studies were performed. The accumulated amount of caffeine was twice higher than the aqueous solution for the microparticle-loaded organogels at 24 h (8262,673 mu g/cm(2) versus 4676,691 mu g/cm(2)). It was related to the sustained behaviour of caffeine release from the microparticles. As a result, lecithin organogel containing HA-encapsulated microparticles could be considered as suitable candidate formulations for efficient topical drug delivery system of caffeine. In addition to that, synergistic effect of this combination appears as a promising approach for long-acting treatment of cellulite.en_US
dc.description.sponsorshipResearch Foundation of Ege UniversityEge University [12/ECZ/029]; TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [111S183]en_US
dc.description.sponsorshipThis study was supported by the Research Foundation of Ege University (Grant Number 12/ECZ/029). The authors are grateful to Prof. Hande Gurer Orhan from Ege University, Faculty of Pharmacy, Department of Toxicology for conducting cell culture studies and Ege University, Faculty of Pharmacy, Pharmaceutical Sciences Research Centre (FABAL) for equipmental support in UPLC analysis. The authors would also like to thank TUBITAK for purchasing of the spray dryer under the project number 111S183.en_US
dc.identifier.doi10.1208/s12249-018-0955-xen_US
dc.identifier.endpage1376en_US
dc.identifier.issn1530-9932
dc.identifier.issue3en_US
dc.identifier.pmid29380282en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1367en_US
dc.identifier.urihttps://doi.org/10.1208/s12249-018-0955-x
dc.identifier.urihttps://hdl.handle.net/11454/30547
dc.identifier.volume19en_US
dc.identifier.wosWOS:000428932700038en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAaps Pharmscitechen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcaffeineen_US
dc.subjecthyaluronan microparticlesen_US
dc.subjectorganogelen_US
dc.subjectcelluliteen_US
dc.subjectskin permeationen_US
dc.titleFormulation and Evaluation of Organogels Containing Hyaluronan Microparticles for Topical Delivery of Caffeineen_US
dc.typeArticleen_US

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