Changes of Ki-67 index in squamous cell carcinoma of the cervix during the early course of radiotherapy and prediction of prognosis

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dc.contributor.authorKamer, SA
dc.contributor.authorYalman, D
dc.contributor.authorOzer, E
dc.contributor.authorSayhan, S
dc.contributor.authorHanhan, M
dc.contributor.authorOzsaran, A
dc.contributor.authorHaydaroglu, A
dc.date.accessioned2019-10-27T19:02:30Z
dc.date.available2019-10-27T19:02:30Z
dc.date.issued2003
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose: To determine whether changes in the Ki-67 index during the early course of radiotherapy could predict the prognosis in squamous cell carcinoma-of the uterine cervix and be of value in clinical practice. Materials and Methods: Biopsy specimens from 23 cases of histologically confirmed squamous cell carcinoma of the cervix were stained with anti-Ki-67 monoclonal antibody prior to radiotherapy and after 9 Gy. The correlation between the Ki-67 index, local control and distant metastasis was determined by Spearman's correlation test. Results: Median age of the patients was 49. According to the FIGO staging system four patients had Stage IIA, 16 had Stage IIB, one had Stage IIIA and two had Stage IIIB disease. Among the whole group brachytherapy was applied to 17 patients (17/23) and weekly cisplatin (40 mg/m(2)) was applied to 15 patients (15/23). The mean Ki-67 index prior to radiotherapy and after 9 Gy for the entire group were 58.5% and 46.0%, respectively. The Ki-67 index after 9 Gy decreased in most of the patients (74%). During a median follow-up of 23 months four patients developed local recurrence and four patients developed distant metastasis. No significant correlation was detected among the local control and changes in Ki-67 index after 9 Gy, whereas there was a moderate correlation between distant metastasis and changes in Ki-67 index after 9 Gy (r = 0.51, p = 0.01). Conclusion: The Ki-67 index can be used safely as a proliferation marker in cervical carcinomas, and changes in the Ki-67 index during the early course of radiotherapy may predict the metastatic potential. However prospective studies including a large number of patients with long-term follow-up are necessary to confirm the clinical utility of this marker in cervical cancer.en_US
dc.identifier.endpage292en_US
dc.identifier.issn0392-2936
dc.identifier.issue03.Apren_US
dc.identifier.pmid12807242en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage287en_US
dc.identifier.urihttps://hdl.handle.net/11454/38017
dc.identifier.volume24en_US
dc.identifier.wosWOS:000183345700017en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherI R O G Canada, Incen_US
dc.relation.ispartofEuropean Journal of Gynaecological Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcarcinoma of the cervixen_US
dc.subjectradiotherapyen_US
dc.subjectKi-67 indexen_US
dc.titleChanges of Ki-67 index in squamous cell carcinoma of the cervix during the early course of radiotherapy and prediction of prognosisen_US
dc.typeArticleen_US

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