The effect of serum lipid levels on peripheral blood hematopoietic stem cell levels

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dc.authoridAk, Gunes/0000-0001-6780-1812
dc.authoridComert, melda/0000-0002-7798-4349
dc.authoridKABAROGLU, CEYDA/0000-0002-6968-707X
dc.authoridDonmez, Ayhan/0000-0002-7304-5424
dc.authoridYILDIRIM SIMSIR, ILGIN/0000-0002-6801-8499
dc.authorwosidAk, Gunes/AAA-6769-2020
dc.authorwosidComert, melda/ABH-5764-2020
dc.contributor.authorSimsir, Ilgin Yildirim
dc.contributor.authorDonmez, Ayhan
dc.contributor.authorKabaroglu, Ceyda
dc.contributor.authorYavasoglu, Irfan
dc.contributor.authorBasol, Gunes
dc.contributor.authorGungor, Ayse
dc.contributor.authorOzkan, Melda Comert
dc.date.accessioned2023-01-12T19:58:26Z
dc.date.available2023-01-12T19:58:26Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractIntroduction: There are limited numbers of available retrospective studies on various hematological diseases treated with stem cell mobilization therapy. In the present study, we aimed to demonstrate the effects of serum lipid levels on peripheral blood CD34+ (PBCD34+) cell counts as well as the changes in serum lipid levels during stem cell mobilization process. Method: PBCD34+ cell counts were compared between hypercholesterolemic patients and healthy individuals. Additionally, total cholesterol (TChol), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), and triglyceride (TG) levels were measured from healthy donors who underwent stem cell mobilization, at different time points (prior to filgrastim [phase 1], prior to apheresis [phase II], and the first week following apheresis [phase III]. Results: In the hypercholesterolemia group, the PBCD34+ cell count was found to be higher among patients with elevated LDL-C (2.6 +/- 0.35/mu L vs. 1.7 +/- 0.17/mu L, p = 0.003) and TChol (2.6 +/- 0.34/mu L vs. 1.7 +/- 0.14/mu L, p = 0.006) in comparison to the healthy controls. In the mobilization group, phase II HDL-C levels (35.3 +/- 2.8 mg/ dL) were found to be lower than both phase I (45.6 +/- 2.1 mg/dL) and phase III (44.5 +/- 2.6 mg/dL) (p = 0.007). Phase II TChol levels (183.5 +/- 10.0 mg/dL) were lower than both phase I (216.8 +/- 8.5 mg/dL) and phase III (212.2 +/- 8.4 mg/dL) (p = 0.02). At phase II, there was an inverse correlation between PBCD34+ cell count and HDL-C (r = - 0.57, p = 0.003). Discussion: Our results indicate that, while increased LDL-C level is the determinant of baseline PBCD34+ cell count, reduced HDL-C is the determinant of PBCD34+ cell count during mobilization process.en_US
dc.description.sponsorshipTurkish Society of Hematology, Turkey [2013/5, 12-5/3]en_US
dc.description.sponsorshipThis project was supported by the Turkish Society of Hematology, Turkey (2013/5, Ege University Research Ethics Committee Decision Number: 12-5/3).en_US
dc.identifier.doi10.1016/j.transci.2021.103074
dc.identifier.issn1473-0502
dc.identifier.issn1878-1683
dc.identifier.issue3en_US
dc.identifier.pmid33574011en_US
dc.identifier.urihttps://doi.org/10.1016/j.transci.2021.103074
dc.identifier.urihttps://hdl.handle.net/11454/76905
dc.identifier.volume60en_US
dc.identifier.wosWOS:000669589300005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTransfusion and Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHematopoietic stem cellen_US
dc.subjectCholesterolen_US
dc.subjectMobilizationen_US
dc.subjectLipid levelsen_US
dc.subjectDensity-Lipoproteinen_US
dc.subjectMobilizationen_US
dc.subjectHypercholesterolemiaen_US
dc.subjectCholesterolen_US
dc.titleThe effect of serum lipid levels on peripheral blood hematopoietic stem cell levelsen_US
dc.typeArticleen_US

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