Effect of dietary n-3 fatty acids on hypoxia-induced necrotizing enterocolitis in young mice. n-3 fatty acids alter platelet-activating factor and leukotriene B4 production in the intestine

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dc.contributor.authorAkisü M.
dc.contributor.authorBaka M.
dc.contributor.authorÇoker I.
dc.contributor.authorKültürsay N.
dc.contributor.authorHüseyinov A.
dc.date.accessioned2019-10-27T09:00:34Z
dc.date.available2019-10-27T09:00:34Z
dc.date.issued1998
dc.departmentEge Üniversitesien_US
dc.description.abstractNecrotizing entercolitis (NEC) is an important neonatal disease with a high mortality rate. Inflammatory mediators, such as mainly platelet-activating factor (PAF), leukotrienes (LT) and tumor necrosis factor play an important role in the genesis of NEC. Diets in ??3 (n-3) fatty acids appear to have an antiinflammatory effect, which is thought to be due to decreased active prostaglandins and leukotrienes production after incorporation of these fatty acids into cell membranephospholipids. We investigated the protective effect of fish oil (source of n-3 fatty acids) on hypoxia-induced model of NEC. Young mice were divided into three groups group 1 mice were fed standard chow (n-3 fatty acids-free), group 2 was fed a chow supplemented by 10% fish oil for 4 weeks. Group 3 mice served as control. We examined the intestinal lesions by light microscopy and measured intestinal tissue PAF and LB4 levels in hypoxia-induced model of NEC. Significantly increased intestinal PAF and LTB4 levels were found in group 1 mice when compared to group 2 and group 3 mice. The histopathology of the intestinal lesions in group 1 animals was characteristic of ischemic injury. In the n-3 fatty acids-supplemented animals these lesions were milder. The present study shows that endogenously released PAF and LTB4 play an important role in mediating hypoxia-induced intestinal necrosis. The present study also suggests that dietary supplementation with n-3 fatty acids suppress intestinal PAF and LTB4 generation in hypoxia-induced bowel necrosis. The intestinal protective effect of n-3 fatty acids in an experimental model of NEC may open new insight into the treatment and preventation of NEC in neonates.en_US
dc.identifier.doi10.1159/000014008en_US
dc.identifier.endpage38en_US
dc.identifier.issn0006-3126
dc.identifier.issue1en_US
dc.identifier.pmid9657667en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage31en_US
dc.identifier.urihttps://doi.org/10.1159/000014008
dc.identifier.urihttps://hdl.handle.net/11454/28088
dc.identifier.volume74en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofBiology of the Neonateen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFish oilen_US
dc.subjectLeukotrienesen_US
dc.subjectNecrotizing enterocolitisen_US
dc.subjectOmega-3 fatty acidsen_US
dc.subjectPlatelet-activating factoren_US
dc.titleEffect of dietary n-3 fatty acids on hypoxia-induced necrotizing enterocolitis in young mice. n-3 fatty acids alter platelet-activating factor and leukotriene B4 production in the intestineen_US
dc.typeArticleen_US

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