Accumulation of alpha-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markers

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dc.contributor.authorSolmaz, Volkan
dc.contributor.authorOzlece, Hatice Kose
dc.contributor.authorEroglu, Huseyin Avni
dc.contributor.authorAktug, Huseyin
dc.contributor.authorErbas, Oytun
dc.contributor.authorTaskiran, Dilek
dc.date.accessioned2019-10-27T11:22:56Z
dc.date.available2019-10-27T11:22:56Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective. The present study was conducted to evaluate the relationship between plasma oxidative stress markers such as malondialdehyde (MDA) and glutathione (GSH), inflammatory marker pentraxin-3 (PTX3), and cerebellar accumulation of alpha-synuclein in streptozotocin-(STZ-) induced diabetes model in rats. Methods. Twelve rats were included in the study. Diabetes (p = 6) was induced with a single intraperitoneal injection of streptozotocin (STZ, 60 mg/kg). Diabetes was verified after 48 h by measuring blood glucose levels. Six rats served as controls. Following 8 weeks, rats were sacrificed for biochemical and immunohistochemical evaluation. Results. Plasma MDA levels were significantly higher in diabetic rats when compared with the control rats (p < 0.01), while plasma GSH levels were lower in the diabetic group than in the control group (p < 0.01). Also, plasma pentraxin-3 levels were statistically higher in diabetic rats than in the control rats (p < 0.01). The analysis of cerebellar alpha-synuclein immunohistochemistry showed a significant increase in alpha-synuclein immunoexpression in the diabetic group compared to the control group (p < 0.01). Conclusion. Due to increased inflammation and oxidative stress in the chronic period of hyperglycemia linked to diabetes, there may be alpha-synuclein accumulation in the cerebellum and the plasma PTX3 levels may be assessed as an important biomarker of this situation.en_US
dc.identifier.doi10.1155/2017/5952149en_US
dc.identifier.issn2090-1852
dc.identifier.issn2090-1860
dc.identifier.pmid28133547en_US
dc.identifier.urihttps://doi.org/10.1155/2017/5952149
dc.identifier.urihttps://hdl.handle.net/11454/33105
dc.identifier.wosWOS:000392134300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Publishing Corpen_US
dc.relation.ispartofNeurology Research Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleAccumulation of alpha-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markersen_US
dc.typeArticleen_US

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